2-(benzylamino)cyclopentanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(benzylamino)cyclopentanol
• 英文别名: 2-(Benzylamino)cyclopentan-1-OL
• 化学式: C₁₂H₁₇NO
• 分子量: 191.273
• InChiKey: FEGVMDAESGIXLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,2-环氧环戊烷 、 苄胺 在 zirconium(IV) sulfate 作用下， 反应 2.83h， 以66%的产率得到2-(benzylamino)cyclopentanol
  参考文献：
  名称：

  Microwave-Enhanced Sulphated Zirconia and SZ/MCM-41 Catalyzed Regioselective Synthesis of β-Amino Alcohols Under Solvent-Free Conditions

  摘要：

  本文介绍了一种无溶剂方法，与传统加热法相比，它能以更短的反应时间和更高的产率进行 β-氨基醇的区域选择性合成。该方法涉及在硫酸化锆 (SZ) 或硫酸化锆包覆 MCM-41 (SZM) 作为催化剂的情况下，对未稀释的反应物进行微波 (MW) 暴露。这两种酸性材料都很容易回收和重复使用。

  DOI：

  10.3390/molecules13040977

文献信息

• Substituted Imidazopyridines as HDM2 Inhibitors
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20140179680A1

  公开（公告）日：2014-06-26

  The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.

  本发明提供了如本文所述的取代咪唑吡啶或其药用可接受的盐或溶剂。代表性化合物可用作HDM2蛋白的抑制剂。还公开了包括上述化合物的药物组合物以及使用它们治疗癌症的潜在方法。
• [EN] METHODS FOR PREPARING FLUOROALKYL ARYLSULFINYL COMPOUNDS AND FLUORINATED COMPOUNDS THERETO<br/>[FR] PROCÉDÉS DE PRÉPARATION DE COMPOSÉS FLUOROALKYLE ARYLSULFINYLÉS ET COMPOSÉS FLUORÉS APPARENTÉS
  申请人：IM & T RES INC

  公开号：WO2010022001A1

  公开（公告）日：2010-02-25

  Novel preparative methods for fluoroalkyl arylsulfinyl compounds are disclosed. Fluorinated compounds as useful fluorinated compounds, intermediates, or builing blocks are disclosed. Useful applications of the fluoroalkyl arylsulfinyl compounds are shown.

  揭示了用于制备氟烷基芳基磺酰基化合物的新型制备方法。公开了氟化合物作为有用的氟化合物、中间体或构建块。展示了氟烷基芳基磺酰基化合物的有用应用。
• Comparative Study of Regioselective Synthesis of β-Aminoalcohols under Solventless Conditions Catalyzed by Sulfated Zirconia and SZ/MCM-41
  作者：Guillermo Negrón-Silva、C. Hernández-Reyes、Deyanira Angeles-Beltrán、Leticia Lomas-Romero、Eduardo González-Zamora、Juan Méndez-Vivar

  DOI：10.3390/12112515

  日期：——

  Sulfated zirconia and SZ/MCM-41 were used as catalysts for the synthesis of β-aminoalcohols via epoxide aminolysis. Sulfated zirconia was prepared by sol-gel andSZ/MCM-41 was obtained by impregnation. Solid catalysts were characterized by XRD,SEM-EDS, UV-Vis, FT-IR pyridine desorption and Nitrogen physisorption. Both acidmaterials were useful as catalysts, even when they were recycled several times. The β-aminoalcohols were characterized by FT-IR, 1H- and 13C-NMR and GC-MS.

  硫酸化氧化锆和 SZ/MCM-41 被用作催化剂，通过环氧化物氨解合成 β-氨基醇。硫酸化氧化锆通过溶胶-凝胶法制备，SZ/MCM-41 通过浸渍法制备。固体催化剂通过 XRD、SEM-EDS、UV-Vis、FT-IR 吡啶解吸和氮物理吸附进行了表征。这两种酸性材料作为催化剂都很有用，甚至可以多次循环使用。傅立叶变换红外光谱、1H- 和 13C-NMR 以及气相色谱-质谱对 β-氨基丙醇进行了表征。
• Methods For Preparing Fluoroalkyl Arylsulfinyl Compounds And Fluorinated Compounds Thereto
  申请人：Umemoto Teruo

  公开号：US20110190511A1

  公开（公告）日：2011-08-04

  Novel preparative methods for fluoroalkyl arylsulfinyl compounds are disclosed. Fluorinated compounds as useful fluorinated compounds, intermediates, or builing blocks are disclosed. Useful applications of the fluoroalkyl arylsulfinyl compounds are shown.

  本发明揭示了一种用于制备氟烷基芳基亚磺酰化合物的新型制备方法。本发明还揭示了氟化合物作为有用的氟化合物、中间体或构建块。同时，本发明还展示了氟烷基芳基亚磺酰化合物的有用应用。
• Methods for Preparing Fluoroalkyl Arylsulfinyl Compounds and Fluorinated Compounds Thereto
  申请人：Umemoto Teruo

  公开号：US20100152463A1

  公开（公告）日：2010-06-17

  Novel preparative methods for fluoroalkyl arylsulfinyl compounds are disclosed. Fluorinated compounds as useful fluorinated compounds, intermediates, or building blocks are disclosed. Useful applications of the fluoroalkyl arylsulfinyl compounds are shown.

  本发明公开了用于制备氟烷基芳基磺酰基化合物的新型制备方法。本发明还公开了作为有用的氟化合物、中间体或构建块的氟化合物。本发明还展示了氟烷基芳基磺酰基化合物的有用应用。