二鲸蜡醇硫代二丙酸酯 | 3287-12-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 二鲸蜡醇硫代二丙酸酯
• 英文名称: dihexadecyl 3,3'-thiodipropionate
• 英文别名: 4-thia-heptanedioic acid dihexadecyl ester；Bis-(2-hexadecyloxycarbonyl-aethyl)-sulfid；4-Thia-heptandisaeure-dihexadecylester；dihexadecyl 3,3'-thiobispropionate；Propanoic acid, 3,3'-thiobis-, dihexadecyl ester；hexadecyl 3-(3-hexadecoxy-3-oxopropyl)sulfanylpropanoate
• CAS: 3287-12-5
• 化学式: C₃₈H₇₄O₄S
• 分子量: 627.069
• InChiKey: IXDBUVCZCLQKJF-UHFFFAOYSA-N

物化性质

• 熔点：
  59-62 °C
• 沸点：
  665.4±40.0 °C(Predicted)
• 密度：
  0.926±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  16
• 重原子数：
  43
• 可旋转键数：
  38
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  77.9
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2930909090

反应信息

• 作为产物：
  描述：

  硫代二丙酸 、 1-十六烷醇 在 Novozym 435 作用下， 80.0 ℃ 、80.0 kPa 条件下， 反应 4.0h， 以84%的产率得到二鲸蜡醇硫代二丙酸酯
  参考文献：
  名称：

  Dialkyl 3,3‘-Thiodipropionate and Dialkyl 2,2‘-Thiodiacetate Antioxidants by Lipase-Catalyzed Esterification and Transesterification

  摘要：

  Medium- and long-chain dialkyl 3,3'-thiodipropionate antioxiclants such as dioctyl 3,3'-thiodipropionate, didodecyl 3,3'-thiodipropionate, clihexadecyl 3,3'-thiodipropionate, and di-(cis-9-octadecenyl) 3,3'-thiodipropionate were prepared in high yield by lipase-catalyzed esterification and transesterification of 3,3'-thiodipropionic acid and its dimethyl ester, respectively, with the corresponding medium- or long-chain 1-alkanols, i.e., 1-octanol, 1-dodecanol, 1-hexadecanol, and cis-9-octadecen-1-ol, in vacuo (80 kPa) at moderate temperatures (60-80 degrees C) without solvents. Immobilized lipase B from Candida antarctica (Novozym 435) was the most active biocatalyst for the preparation of medium- and longchain dialkyl 3,3'-thiodipropionates showing enzyme activities up to 1489 units/g, whereas the immobilized lipases from Phizomucor miehei (Lipozyme RM IM) and Thermomyces lanuginosus (Lipozyme TL IM) were by far less active (similar to 10 enzyme units/g). Maximum conversions to dialkyl 3,3'-thiodipropionates were as high as 92-98% after 4 h of reaction time. Similarly, dihexadecyl 2,2'-thiodiacetate was prepared in high yield using 2,2'-thiodiacetic acid or diethyl 2,2'-thiodiacetate and 1-hexaclecanol as the starting materials and Novozym 435 as the biocatalyst.

  DOI：

  10.1021/jf0530502

文献信息

• [EN] ACRYLATE-FUNCTIONAL BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ À FONCTION ACRYLATE, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
  申请人：DOW SILICONES CORP

  公开号：WO2020142474A1

  公开（公告）日：2020-07-09

  A method of preparing an acrylate-functional branched organosilicon compound ("compound") is provided, and comprises reacting (A) a branched organosilicon compound and (B) an acrylate compound in the presence of (C) a catalyst, wherein component (A) has the general formula X-Si(R1)3, where X comprises a halogen-functional moiety and each R1 is selected from R and –OSi(R4)3, with the proviso that at least one R1 is –OSi(R4)3; each R4 is selected from R, –OSi(R5)3, and –[OSiR2]mOSiR3; each R5 is selected from R, –OSi(R6)3, and –[OSiR2]mOSiR3; each R6 is selected from R and –[OSiR2]mOSiR3; each R is an independently selected hydrocarbyl group; and 0≤m≤100; with the proviso that at least one of R4, R5 and R6 is –[OSiR2]mOSiR3. The compound prepared by the method, a copolymer comprising the reaction product of the compound and a second compound, a method of forming the copolymer, and a composition comprising the copolymer are each also provided.

  提供了一种制备丙烯酸酯官能化分支有机硅化合物（“化合物”）的方法，包括在催化剂存在下，使（A）分支有机硅化合物和（B）丙烯酸酯化合物发生反应，其中组分（A）具有一般式X-Si（R1）3，其中X包括卤素官能基，每个R1从R和–OSi（R4）3中选择，但至少一个R1为–OSi（R4）3；每个R4从R、–OSi（R5）3和–[OSiR2]mOSiR3中选择；每个R5从R、–OSi（R6）3和–[OSiR2]mOSiR3中选择；每个R6从R和–[OSiR2]mOSiR3中选择；每个R是独立选择的烃基；且0≤m≤100；但至少一个R4、R5和R6为–[OSiR2]mOSiR3。还提供了通过该方法制备的化合物，包括化合物和第二化合物的反应产物的共聚物，形成共聚物的方法，以及包含共聚物的组合物。
• Topical and oral formulations of cardiac glycosides for treating skin diseases
  申请人：Streeper Robert

  公开号：US20060205679A1

  公开（公告）日：2006-09-14

  The present invention provides method, preparation and use of a variety of pharmaceutical compositions containing at least one digitalis glycoside such as oleandrin, odoroside-A, neriifolin, proscillaridin-A, methyl-proscillaridin-A, digitoxin, digoxin alone or at least one digitalis glycoside complexed with cyclodextrins. In another aspect, the present invention provides an effective method to treat diseases in mammals. In yet another aspect, the present invention provides an effective method for treating skin diseases in a human or non-human animal.

  本发明提供了一种方法、制备和使用多种含有至少一种毛地黄苷类药物成分的药物组合物，例如奥利安定、奥多罗苷A、内里福林、普罗斯西拉里丁A、甲基普罗斯西拉里丁A、地高辛、地高辛或至少一种毛地黄苷类与环糊精络合的药物。另一方面，本发明提供了一种有效的方法来治疗哺乳动物的疾病。另一方面，本发明提供了一种有效的方法来治疗人类或非人类动物的皮肤疾病。
• HYDROXYTYROSOL DERIVATIVES, THEIR METHOD OF PREPARATION AND USE IN PERSONAL CARE
  申请人：Eastman Chemical Company

  公开号：US20150126759A1

  公开（公告）日：2015-05-07

  Hydroxytyrosol derivative compositions, methods for their manufacture, and their use in personal care products are disclosed. Lipophilic hydroxytyrosol carbonate ester compound can be made by oxidizing a substituted hydroxybenzaldehyde compound with an oxidizing agent such as hydrogen peroxide under mild conditions. The process involves enzymatic esterification of 4-(2-hydroxyethyl)phenol to form the corresponding ester, the introduction of a formyl group ortho to the phenolic hydroxyl group of the ester to form a lipophilic formyltyrosol ester; oxidation of the lipophilic formyltyrosol ester with a peroxide compound to form a lipophilic hydroxytyrosol ester compound; and reaction of lipophilic hydroxytyrosol ester compound with carbonic acid ester derivatives to form a lipophilic hydroxytyrosol carbonic ester compound. These compounds are useful is a wide variety of personal care compositions as anti-aging compounds that are stable against oxidation.

  披露了羟基酪醇衍生物组合物的制造方法，以及它们在个人护理产品中的应用。脂溶性羟基酪醇碳酸酯化合物可以通过将取代羟基苯甲醛化合物与氧化剂（如过氧化氢）在温和条件下氧化而制得。该过程涉及酶催化的4-(2-羟乙基)酚酯化反应，形成相应的酯化物，将羟基酯的酚羟基正对位引入一个甲酰基，形成一个脂溶性甲酰酪醇酯；将脂溶性甲酰酪醇酯与过氧化物化合物氧化，形成脂溶性羟基酪醇酯化合物；以及将脂溶性羟基酪醇酯化合物与碳酸酯衍生物反应，形成脂溶性羟基酪醇碳酸酯化合物。这些化合物对于各种个人护理产品都很有用，作为抗衰老化合物，具有抗氧化稳定性。
• [EN] BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
  申请人：DOW SILICONES CORP

  公开号：WO2020142370A1

  公开（公告）日：2020-07-09

  A branched organosilicon compound ("compound") having the general formula (R1)3Si- X-Y is provided. In the formula: each R1 is selected from R and -OSi(R4)3, with the proviso that at least one R1 is -OSi(R4)3; each R is independently a substituted or unsubstituted hydrocarbyl group; each R4 is selected from R, -OSi(R5)3, and -[OSiR2]mOSiR3; each R5 is selected from R, -OSi(R6)3, and -[OSiR2]mOSiR3; each R6 is selected from R and -[OSiR2]mOSiR3; with the proviso that at least one of R4, R5 and R6 is -[OSiR2]mOSiR3; 0

  提供具有一般式（R1）3Si-X-Y的分支有机硅化合物（“化合物”）。在该式中：每个R1从R和-OSi（R4）3中选择，但至少有一个R1为-OSi（R4）3；每个R都是独立的取代或未取代的烃基团；每个R4从R、-OSi（R5）3和-[OSiR2]mOSiR3中选择；每个R5从R、-OSi（R6）3和-[OSiR2]mOSiR3中选择；每个R6从R和-[OSiR2]mOSiR3中选择；但至少有一个R4、R5和R6为-[OSiR2]mOSiR3；0
• Esters of capsaicinoids as dietary supplements
  申请人：Singh Chandra Ulagaraj

  公开号：US20100120912A1

  公开（公告）日：2010-05-13

  Provided are nutraceutical or dietary supplemental compositions comprising esterified capsaicinoids. The esterified capsaicinoids may converted to the active parent capsaicinoid compound following enzymatic or chemical hydrolysis. In various embodiments, these esterified capsaicinoids have a higher lipophilicity, lipid solubility and result in less irritation to the stomach than the parent capsaicinoid, and hence may be included in certain dietary supplement formulations, including capsules, pills and tablets dietary supplement formulations. The dietary supplement compositions may be used for pain management in mammals in vivo and/or in the treatment of various pathological conditions in humans.

  提供的是含酯化辣椒素的营养保健品或膳食补充剂组合物。酯化辣椒素可以在酶解或化学水解后转化为活性母辣椒素化合物。在各种实施方式中，这些酯化辣椒素具有较高的亲脂性、脂溶性，对胃部的刺激较小，因此可以包含在某些膳食补充剂配方中，包括胶囊、药丸和片剂膳食补充剂配方。这些膳食补充剂组合物可用于体内哺乳动物的疼痛管理和/或用于治疗人类的各种病理状况。