4-methyl-N-[2,2,2-trifluoro-1-(4-methylphenyl)ethyl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-[2,2,2-trifluoro-1-(4-methylphenyl)ethyl]benzenesulfonamide
• 化学式: C₁₆H₁₆F₃NO₂S
• 分子量: 343.37
• InChiKey: KNFOOSXEQQDMCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  三氟碘甲烷 、 (E)-N-4-methylbenzylidene-4-toluenesulfonamide 在 四(二甲氨基)乙烯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以84%的产率得到4-methyl-N-[2,2,2-trifluoro-1-(4-methylphenyl)ethyl]benzenesulfonamide
  参考文献：
  名称：

  Nucleophilic Trifluoromethylation of Imines Using the CF₃I/TDAE Reagent

  摘要：

  The nucleophilic trifluoromethylation reagent derived from CF3I and tetrakis(dimethylamino)ethylene (TDAE) was found to be effective in addition to both N-tosyl aldimines and N-tolyl sulfinimines, the latter reaction exhibiting very good diastereoselectivity.

  DOI：

  10.1021/jo050483v

文献信息

• Lewis Base-Catalyzed Perfluoroalkylation of Carbonyl Compounds and Imines with (Perfluoroalkyl)trimethylsilane
  作者：Yoshikazu Kawano、Nobuya Kaneko、Teruaki Mukaiyama

  DOI：10.1246/bcsj.79.1133

  日期：2006.7

  Lewis base-catalyzed perfluoroalkylation of carbonyl compounds and aldimines with (perfluoroalkyl)trimethylsilanes (TMSCF3, TMSC2F5, and TMSC3F7) is described. The nitrogen- or oxygen-containing an...

  描述了路易斯碱催化羰基化合物和醛亚胺与（全氟烷基）三甲基硅烷（TMSCF3、TMSC2F5 和 TMSC3F7）的全氟烷基化。含氮或含氧...
• Lewis Base-catalyzed Trifluoromethylation of Aldimines with (Trifluoromethyl)trimethylsilane
  作者：Yoshikazu Kawano、Hidehiko Fujisawa、Teruaki Mukaiyama

  DOI：10.1246/cl.2005.422

  日期：2005.3

  A catalytic trifluoromethylation of various aldimines with (trifluoromethyl)trimethylsilane in the presence of Lewis bases such as lithium acetate or benzoate proceeded smoothly to afford the corresponding trifluoromethylated adducts in good yields.

  在路易斯碱（如醋酸锂或苯甲酸锂）存在下，用（三氟甲基）三甲基硅烷催化各种醛亚胺的三氟甲基化反应进行顺利，并以良好的收率得到相应的三氟甲基化加合物。
• Nucleophilic Trifluoromethylation of Imines Using the CF₃I/TDAE Reagent
  作者：Wei Xu、William R. Dolbier

  DOI：10.1021/jo050483v

  日期：2005.6.1

  The nucleophilic trifluoromethylation reagent derived from CF3I and tetrakis(dimethylamino)ethylene (TDAE) was found to be effective in addition to both N-tosyl aldimines and N-tolyl sulfinimines, the latter reaction exhibiting very good diastereoselectivity.