邻甲氧基苄肼盐酸盐 | 784189-95-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 邻甲氧基苄肼盐酸盐
• 英文名称: 2-Methoxybenzylhydrazine dihydrochloride
• 英文别名: (2-methoxyphenyl)methylhydrazine;dihydrochloride
• CAS: 784189-95-3
• 化学式: C8H14Cl2N2O
• 分子量: 225.11
• InChiKey: BMMCIHBHZDAFSP-UHFFFAOYSA-N

物化性质

• 熔点：
  118-120

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  47.3
• 氢给体数：
  4
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT

文献信息

• Phosphodiesterase 4 inhibitors
  申请人：Dunn F. Robert

  公开号：US20070254913A1

  公开（公告）日：2007-11-01

  Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

  选择性PDE4抑制是通过芳基和杂环基吡唑化合物实现的。与罗利普兰（rolipram）等化合物相比，这些化合物表现出更好的PDE4抑制作用，并且在抑制其他类PDE时表现出选择性。
• ISOCARBOSTYRIL ALKALOID DERIVATIVES HAVING ANTI-PROLIFERATIVE AND ANTI-MIGRATORY ACTIVITIES
  申请人：Ingrassia Laurent

  公开号：US20100076005A1

  公开（公告）日：2010-03-25

  Isocarbostyril alkaloid derivatives having an anti-proliferative and anti-migratory activities are disclosed. In particular, compounds of formula (I) or (II), as well as stereoisomers, tautomers, racemates, prodrugs, metabolites thereof, pharmaceutically acceptable salt and/or solvate are encompassed which are useful in the treatment and prophylaxis of cancer. Methods of preparation are also disclosed.

  揭示了具有抗增殖和抗迁移活性的异喹啉生物碱衍生物。具体来说，公开了符合以下化学式(I)或(II)的化合物，以及其立体异构体、互变异构体、消旋体、前药、代谢物、药学上可接受的盐和/或溶剂，这些化合物在癌症的治疗和预防中很有用。还公开了制备方法。
• [EN] PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS<br/>[FR] DERIVES DU PYRAZOLE INHIBITEURS DE LA PHOSPHODIESTERASE 4
  申请人：MEMORY PHARM CORP

  公开号：WO2004094411A1

  公开（公告）日：2004-11-04

  Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

  通过芳基和杂环芳基吡唑化合物实现选择性PDE4抑制。与罗利普兰等化合物相比，这些化合物表现出更好的PDE4抑制作用，并且在抑制其他类PDEs方面表现出选择性。
• PHOSPHODIESTERASE 4 INHIBITORS
  申请人：Hopper Allen

  公开号：US20090221661A1

  公开（公告）日：2009-09-03

  Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

  选择性PDE4抑制是由芳基和杂环基吡唑化合物实现的。与如Rolipram等化合物相比，这些化合物表现出更好的PDE4抑制作用，并且在抑制其他类别的PDE方面表现出选择性。
• PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS
  申请人：Memory Pharmaceuticals Corporation

  公开号：EP1631568A1

  公开（公告）日：2006-03-08