N-(t-butoxycarbonylaminoethyl)-glycine ethyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(t-butoxycarbonylaminoethyl)-glycine ethyl ester
• 英文别名: Ethyl 2-[1-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]acetate
• 化学式: C₁₁H₂₂N₂O₄
• 分子量: 246.307
• InChiKey: QDCNVUXRDXCCPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  BH3CN 、 N-叔丁氧羰基-2-氨基乙醛 、 2-胺基乙酸乙酯 生成 N-(t-butoxycarbonylaminoethyl)-glycine ethyl ester
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Peptide nucleic acids
  申请人：——

  公开号：US20030180734A1

  公开（公告）日：2003-09-25

  A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

  一种新型化合物被称为肽核酸，与互补的单链DNA和RNA比相应的DNA更强烈地结合。肽核酸通常包括配体，如天然存在的DNA碱基，通过适当的连接剂连接到肽骨架上。
• Peptide nucleic acids and synthetic procedures therefor
  申请人：Buchardt Ole

  公开号：US20050009041A1

  公开（公告）日：2005-01-13

  A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

  一种新型化合物，被称为肽核酸，能够比相应的DNA更强烈地结合互补的单链DNA和RNA。肽核酸通常包括配体，如天然存在的DNA碱基，通过适当的连接剂连接到肽骨架上。
• Peptide nucleic acids having 2,6-diaminopurine nucleobases
  申请人：——

  公开号：US20020146718A1

  公开（公告）日：2002-10-10

  A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C 1 -C 8 alkylamine side chains.

  一种新型化合物被称为肽核酸，它们比相应的DNA链和RNA链更强地结合互补的DNA和RNA链，并表现出增加的序列特异性和结合亲和力。该发明的肽核酸包括从天然存在的碱基和连接到聚酰胺骨架的非天然存在的碱基中选择的配体。该发明的一些肽核酸还含有C1-C8烷基胺侧链。
• SEQUENCE SPECIFIC DOUBLE-STRANDED DNA/RNA BINDING COMPOUNDS AND USES THEREOF
  申请人：RAYAN ANWAR

  公开号：US20100284959A1

  公开（公告）日：2010-11-11

  The present invention provides specific double-stranded DNA/RNA binding compounds having a polymeric structure, which are in fact, triplex forming molecules capable of binding tightly and specifically to predetermined sequences in the major groove of double stranded nucleic acid molecules; as well as pharmaceutical compositions comprising thereof. The triplex forming molecules and the pharmaceutical compositions of the invention can be used for various therapeutic applications such as site-specific modulation of gene expression and targeting of DNA or RNA damage, as well as for diagnostic applications in vitro.

  本发明提供了具有聚合结构的特定双链DNA / RNA结合化合物，实际上是三链形成分子，能够紧密而特异地结合到双链核酸分子的主沟槽中的预定序列；以及包括它们的制药组合物。本发明的三链形成分子和制药组合物可用于各种治疗应用，例如位点特异性基因表达调节和DNA或RNA损伤的靶向，以及体外诊断应用。
• PEPTIDE NUCLEIC ACIDS
  申请人：BUCHARDT, Ole

  公开号：EP0586474A1

  公开（公告）日：1994-03-16