3-(3-phenylpropoxy)propan-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3-phenylpropoxy)propan-1-ol
• 英文别名: 1-(3-phenyl-propyloxy)-propanol-(3)；3-Hydroxy-1-(3-phenyl-propyloxy)-propan；(3-Hydroxy-propyl)-(3-phenyl-propyl)-aether
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: JMINNHUTENQXPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-苯乙基-1,3-二恶烷 在 1,1,3,3-四甲基二硅氧烷 、 palladium on carbon 、 camphor-10-sulfonic acid 作用下， 反应 24.0h， 以99%的产率得到3-(3-phenylpropoxy)propan-1-ol
  参考文献：
  名称：

  TMDS–Pd / C：一种将乙缩醛还原为醚的便捷系统

  摘要：

  描述了一种用于将缩醛还原为醚的简单实用的方法。它是基于在布朗斯台德酸作为助催化剂的情况下使用1,1,3,3-四甲基二硅氧烷（TMDS）-Pd / C体系。该反应在温和的条件下进行，并且以高收率获得醚。

  DOI：

  10.1016/j.tetlet.2011.01.038

文献信息

• [EN] CARBOSTYRIL COMPOUND<br/>[FR] DÉRIVÉ DE CARBOSTYRILE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2006035954A1

  公开（公告）日：2006-04-06

  The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

  本发明提供了一种由通式（1）表示的羧基吲哚化合物或其盐，其中A是直链键、较低的烷基烯基或较低的烷基亚烯基；X是氧原子或硫原子；R4和R5分别表示氢原子；羧基吲哚骨架的3和4位置之间的键是单键或双键；R1是氢原子，等等；R2是氢原子，等等；R3是氢原子，等等。本发明的羧基吲哚化合物或其盐诱导TFF的产生，因此可用于治疗和/或预防消化道疾病、口腔疾病、上呼吸道疾病、呼吸道疾病、眼部疾病、癌症和伤口等疾病。
• TMDS–Pd/C: a convenient system for the reduction of acetals to ethers
  作者：Yan Shi、Wissam Dayoub、Guo-Rong Chen、Marc Lemaire

  DOI：10.1016/j.tetlet.2011.01.038

  日期：2011.3

  A simple and practical procedure for the reduction of acetals to ethers is described. It is based on the use of a 1,1,3,3-tetramethyldisiloxane (TMDS)–Pd/C system in the presence of a Brønsted acid as the co-catalyst. The reaction occurs under mild conditions and ethers are obtained in high yields.

  描述了一种用于将缩醛还原为醚的简单实用的方法。它是基于在布朗斯台德酸作为助催化剂的情况下使用1,1,3,3-四甲基二硅氧烷（TMDS）-Pd / C体系。该反应在温和的条件下进行，并且以高收率获得醚。
• Derivatives of 4-(2-amino -1-hydroxyethyl)phenol as agonists of the Beta2 adrenergic receptor
  申请人：Duran Carlos Puig

  公开号：US20090042933A1

  公开（公告）日：2009-02-12

  A compound of formula (I) or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof wherein R 1 is a group chosen from —CH 2 OH and —NHC(O)H; R 2 is a hydrogen atom or R 1 together with R 2 form the group —NH—C(O)—CH═CH—, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R 1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R 2 ; R 3 is chosen from a hydrogen atom, a halogen atom and groups chosen from —SO—R 5 , —SO 2 —R 5 , —NH—CO—NH 2 , —CO—NH 2 , hydantoino, C 1-4 alkyl, C 1-4 alkoxy and —SO 2 NR 5 R 6 ; R 4 is chosen from a hydrogen atom, a halogen atom and a C 1-4 alkyl group; R 5 is chosen from a C 1-4 alkyl group and a C 3-8 cycloalkyl group; R 6 is independently chosen from a hydrogen atom and a C 1-4 alkyl group; n, p and q are independently 0, 1, 2, 3 or 4; m and s are independently 0, 1, 2 or 3; and r is 0, 1 or 2 with the provisos that at least one of m and r is not 0, the sum n+m+p+q+r+s is 7, 8, 9, 10, 11, 12 or 13, and the sum q+r+s is 2, 3, 4, 5 or 6.

  化合物的化学式（I）或其药学上可接受的盐、溶剂化合物或立体异构体，其中R1是从—CH2OH和—NHC（O）H中选择的基团；R2是氢原子或R1与R2一起形成—NH—C（O）—CH═CH—的基团，其中氮原子与持有R1的苯环中的碳原子结合，碳原子与持有R2的苯环中的碳原子结合；R3从氢原子、卤原子和从—SO—R5、—SO2—R5、—NH—CO—NH2、—CO—NH2、hydantoino、C1-4烷基、C1-4烷氧基和—SO2NR5R6中选择的基团；R4从氢原子、卤原子和C1-4烷基中选择；R5从C1-4烷基和C3-8环烷基中选择；R6独立选择从氢原子和C1-4烷基中选择；n、p和q独立选择0、1、2、3或4；m和s独立选择0、1、2或3；r为0、1或2，但至少有一个m和r不为0，n+m+p+q+r+s之和为7、8、9、10、11、12或13，且q+r+s之和为2、3、4、5或6。
• Carbostyril compound
  申请人：Kuroda Takeshi

  公开号：US20070179173A1

  公开（公告）日：2007-08-02

  The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R 4 and R 5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R 1 is a hydrogen atom, etc; R 2 is a hydrogen atom, etc; and R 3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

  本发明提供了一种由通式（1）表示的碳基噻吩化合物或其盐，其中A是直接键，较低的烷基烷基或较低的烷基亚烷基；X是氧原子或硫原子；R4和R5分别表示氢原子；碳基噻吩骨架的3和4位之间的键是单键或双键；R1是氢原子等；R2是氢原子等；R3是氢原子等。本发明的碳基噻吩化合物或其盐能够诱导TFF的产生，因此可用于治疗和/或预防消化道疾病、口腔疾病、上呼吸道疾病、呼吸道疾病、眼部疾病、癌症和伤口等疾病。
• Derivatives of 4-(2-Amino-1-Hydroxyethyl) Phenol as Agonists of the Beta2 Adrenergic Receptor
  申请人：PUIG DURAN Carlos

  公开号：US20120101075A2

  公开（公告）日：2012-04-26

  The present disclosure relates to 4-(2-amino-1-hydroxyethyl)phenol derivatives of formula (I) as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the BETA2 adrenergic receptor.

  本公开涉及式(I)的4-(2-氨基-1-羟乙基)苯酚衍生物，以及包含它们的药物组合物，以及它们作为BETA2肾上腺素能受体激动剂在治疗中的使用。