2-((tetrahydrofuran-2-yl)methoxy)isoindoline-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-((tetrahydrofuran-2-yl)methoxy)isoindoline-1,3-dione
• 英文别名: 2-(Oxolan-2-ylmethoxy)isoindole-1,3-dione
• 化学式: C₁₃H₁₃NO₄
• 分子量: 247.251
• InChiKey: MVDUGWVACHWCIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-1-氟-4-(2-(苯基磺酰基)乙烯基)苯 、 2-((tetrahydrofuran-2-yl)methoxy)isoindoline-1,3-dione 在 二氢吡啶 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以76%的产率得到(E)-2-(4-fluorostyryl)tetrahydrofuran
  参考文献：
  名称：

  供体-受体复合物可实现无金属C（sp3）-C（sp3）裂解和烯丙基化/烯基化的烷氧基自由基生成

  摘要：

  烷氧基是化学和生物学研究必不可少的，普遍的反应性中间体。在这里，我们报告了在可见光诱导的无金属反应条件下，第一批供体-受体配合物使能的烷氧基自由基的产生。Hantzsch酯与N烷氧基衍生物形成了关键的供体-受体配合物，这一点已通过一系列光谱学和机理实验得以阐明。首次使用这种无光催化剂的方法对线性的伯，仲和叔烷氧基进行了选择性的C（sp 3）-C（sp 3）键裂解和烯丙基化/烯基化反应。

  DOI：

  10.1002/anie.201707171
• 作为产物：
  描述：

  四氢糠醇 、 N-羟基邻苯二甲酰亚胺 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 以76%的产率得到2-((tetrahydrofuran-2-yl)methoxy)isoindoline-1,3-dione
  参考文献：
  名称：

  供体-受体复合物可实现无金属C（sp3）-C（sp3）裂解和烯丙基化/烯基化的烷氧基自由基生成

  摘要：

  烷氧基是化学和生物学研究必不可少的，普遍的反应性中间体。在这里，我们报告了在可见光诱导的无金属反应条件下，第一批供体-受体配合物使能的烷氧基自由基的产生。Hantzsch酯与N烷氧基衍生物形成了关键的供体-受体配合物，这一点已通过一系列光谱学和机理实验得以阐明。首次使用这种无光催化剂的方法对线性的伯，仲和叔烷氧基进行了选择性的C（sp 3）-C（sp 3）键裂解和烯丙基化/烯基化反应。

  DOI：

  10.1002/anie.201707171

文献信息

• NASAL DROPS CONTAINING FUSED PYRIDAZINE DERIVATIVES
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1243271A1

  公开（公告）日：2002-09-25

  A nose drop containing the compound (I) represented by the formula wherein Ar1 and Ar2 are each an aromatic group, Ar1 and Ar2 optionally form a condensed cyclic group together with the adjacent carbon atom, ring B is a nitrogen-containing heterocycle, X and Y are each a bond, an oxygen atom or S(O)p (p is 0 to 2), NR4 (R4 is H or a lower alkyl group) or a divalent linear lower hydrocarbon group optionally having substituents and containing 1 to 3 heteroatoms, A is N or CR7 (R7 is H, a halogen atom, a hydrocarbon group, an acyl group or a hydroxy group optionally having substituents), R1, R2 and R3 are each H, a halogen atom, a hydrocarbon group, an acyl group or a hydroxy group optionally having substituents, and R8 is H, a hydroxy group optionally substituted by a lower alkyl group or a carboxyl group, provided that the nitrogen-containing heterocycle represented by ring B is not a heterocycle represented by the formula wherein n is 0 - 1, or a salt thereof or a prodrug thereof, exhibits a superior prophylactic or therapeutic effect on allergic rhinitis and the like.

  一种含有由以下公式表示的化合物（I）的鼻滴 其中Ar1和Ar2各自是芳香基团，Ar1和Ar2可以与相邻的碳原子一起形成紧凑的环状基团，环B是含氮杂环，X和Y各自是键，氧原子或S（O）p（p为0至2），NR4（R4为H或低碳基团）或二价线性低碳氢基团，可选地具有取代基并含有1至3个杂原子，A为N或CR7（R7为H、卤素原子、碳氢基团、酰基或可选地具有取代基的羟基），R1、R2和R3各自为H、卤素原子、碳氢基团、酰基或可选地具有取代基的羟基，以及 R8为H、可选地由低碳基团或羧基取代的羟基，前提是由环B表示的含氮杂环不是由以下公式表示的杂环 其中n为0-1，或其盐或前药，对过敏性鼻炎等表现出卓越的预防或治疗作用。
• Alkylation of Allyl/Alkenyl Sulfones by Deoxygenation of Alkoxyl Radicals
  作者：Jia-Bin Han、Ao Guo、Xiang-Ying Tang

  DOI：10.1002/chem.201806138

  日期：2019.2.26

  challenging deoxygenation of alkoxyl radicals from readily accessible alcohol derivatives was developed, affording facile synthesis of functionalized alkenes with good functional group tolerance under mild reaction conditions. Because alkoxyl radicals can easily undergo β‐fragmentations or hydrogen abstractions, this new strategy for deoxygenation of alkoxyl radicals is highly valuable. Moreover, mechanistic

  从容易获得的醇衍生物开发了具有挑战性的烷氧基自由基脱氧剂，可在温和的反应条件下轻松合成具有良好官能团耐受性的官能化烯烃。由于烷氧基自由基很容易发生β片段分解或夺氢现象，因此这种使烷氧基自由基脱氧的新策略非常有价值。此外，机理研究表明，电子中性膦可作为脱氧剂。
• FUSED PYRIDAZINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1123936A1

  公开（公告）日：2001-08-16

  A compound (I) represented by the formula: wherein Ar1 and Ar2 are Independently an aromatic group optionally having a substituent, and Ar1 and Ar2 may form a condensed cyclic group with an adjacent carbon atom; ring B is a nitrogen-containing heterocycle optionally having a substituent; X and Y are the same or different and are independently a band, an oxygen atom, S(O)p (p is an integer of 0 to 2), NR4 wherein R4 is a hydrogen atom or a lower alkyl group, or a bivalent linear lower hydrocarbon group which may contain 1 to 3 hetero atoms and the bivalent linear lower hydrocarbon group may be substituted; A is a nitrogen atom or CR7 wherein R7 is a hydrogen atom, a halogen atom, a hydrocarbon optionally having a substituent, an acyl group or a hydroxy group optionally having a substituent; R1, R2 and R3 are the same or different and are independently a hydrogen atom, ahalogen atom, ahydrocarbon group optionally having a substituent, an acyl group or a hydroxy group optionally having a substituent; R8 is a hydrogen atom, a hydroxy group which may be substituted by lower alkyl or a carboxyl group, provided that the nitrogen-containing heterocycle represented by ring B is not a heterocycle represented by the formula: wherein n is 0 or 1, or a salt thereof, exhibits excellent anti-allergic, anti-histaminic, anti-inflammatory and eosinophil chemotaxis inhibiting activity and is useful as a pharmaceutical composition for preventing or treating allergic skin diseases such as contact dermatitis, pruritus, dried dermatitis, acute urticaria and prurigo. According to the method for producing of the present invention, the compound (I') represented by the formula: wherein Ar1' and Ar2' are independently an aromatic group optionally having a substituent, and Ar1' and Ar2' may form a condensed cyclic group with an adjacent carbon atom; ring B' is a nitrogen-containing heterocycle optionally having a substituent; X and Y are the same or different and are independently a bond, an oxygen atom, S(O)p (p is an integer of 0 to 2), NR4 wherein R4 is a hydrogen atom or a lower alkyl group, or a bivalent linear lower hydrocarbon group which may contain 1 to 3 hetero atoms and the bivalent linear lower hydrocarbon group may be substituted; A is a nitrogen atom or CR7 wherein R7 is a hydrogen atom, a halogen atom, a hydrocarbon optionally having a substituent, an acyl group or a hydroxy group optionally having a substituent; R1 is a hydrocarbon group substituted with an optionally esterified carboxyl group, R2 and R3 are the same or different and are independently a hydrogen atom, a halogen atom, a hydrocarbon group optionally having a substituent, an acyl group or a hydroxy group optionally having a substituent; R8 is a hydrogen atom, a hydroxy group which may be substituted by lower alkyl or a carboxyl group, or a salt thereof, exhibiting excellent anti-allergic, anti-histaminic, anti-inflammatory and eosinophil chemotaxis inhibiting activity and is useful as a pharmaceutical composition for preventing or treating adthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, chronic urticaria, can be produced in good efficiency and in a high yield. The hydrate of a compound represented by the formula; wherein R is a hydrogen atom or an ethyl group, or a succinate or citrate of the compound (I") exhibits excellent anti-allergic, anti-histaminic, anti-inflammatory and eosinophil chemotaxis inhibiting activity and is useful as a pharmaceutical composition for preventing or treating adthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, chronic urticaria, and has excellent stability.

  一种由式表示的化合物(I)： 其中 Ar1 和 Ar2 独立地为可选具有取代基的芳香基团，且 Ar1 和 Ar2 可与相邻碳原子形成缩合环基；环 B 为可选具有取代基的含氮杂环；X和Y相同或不同，且独立地为带、氧原子、S(O)p（p为0至2的整数）、NR4（其中R4为氢原子或低级烷基）或可含有1至3个杂原子的二价线性低级烃基，且该二价线性低级烃基可被取代；A是氮原子或CR7，其中R7是氢原子、卤素原子、可选具有取代基的烃、酰基或可选具有取代基的羟基；R1、R2和R3相同或不同，且独立地是氢原子、卤素原子、可选具有取代基的烃、酰基或可选具有取代基的羟基；R8 是氢原子、可被低级烷基取代的羟基或羧基，条件是环 B 所代表的含氮杂环不是式中所代表的杂环： 其中 n 为 0 或 1 的杂环，或其盐，具有优异的抗过敏、抗组胺、抗炎和抑制嗜酸性粒细胞趋化的活性，可用作预防或治疗过敏性皮肤病如接触性皮炎、瘙痒症、干燥性皮炎、急性荨麻疹和瘙痒症的药物组合物。 根据本发明的生产方法，由式表示的化合物（I'）： 其中 Ar1'和 Ar2'独立地是任选具有取代基的芳香基团，Ar1'和 Ar2'可与相邻碳原子形成缩合环基；环 B'是任选具有取代基的含氮杂环；X和Y相同或不同，且独立地为键、氧原子、S(O)p（p为0至2的整数）、NR4（其中R4为氢原子或低级烷基）或二价线性低级烃基，该二价线性低级烃基可含有1至3个杂原子，且该二价线性低级烃基可被取代；A为氮原子或CR7（其中R7为氢原子、卤素原子、可选择具有取代基的烃、酰基或可选择具有取代基的羟基）；R1 是被任选酯化羧基取代的烃基，R2 和 R3 相同或不同，且独立地为氢原子、卤素原子、任选具有取代基的烃、酰基或任选具有取代基的羟基；R8 是氢原子、可被低级烷基或羧基取代的羟基或其盐，具有优异的抗过敏、抗组胺、抗炎和抑制嗜酸性粒细胞趋化的活性，可用作预防或治疗哮喘、过敏性鼻炎、特应性皮炎、过敏性结膜炎、慢性荨麻疹的药物组合物，生产效率高，产量大。 由式表示的化合物的水合物； 式中 R 为氢原子或乙基的化合物的水合物，或化合物（I"）的琥珀酸盐或柠檬酸盐，具有优异的抗过敏、抗组胺、抗炎和抑制嗜酸性粒细胞趋化的活性，可用作预防或治疗哮喘、过敏性鼻炎、特应性皮炎、过敏性结膜炎、慢性荨麻疹的药物组合物，并具有优异的稳定性。
• Zn-Mediated Fragmentation of N-Alkoxyphthalimides Enabling the Synthesis of gem-Difluoroalkenes
  作者：Yi-Yue Wang、Wei-Jun Pang、Tie Liu、Jing Sun、Ming-Dong Zhou

  DOI：10.1021/acs.orglett.4c01433

  日期：2024.6.7

  Zn-mediated generation of alkoxyl radicals from N-alkoxyphthalimides emerged as an efficient approach for forming diverse and valuable alkyl radicals through β-scission or a hydrogen atom transfer process. The alkyl radical species can be further trapped by α-trifluoromethyl alkenes to construct a series of gem-difluoroalkenes.

  Zn介导的N-烷氧基邻苯二甲酰亚胺生成烷氧基自由基成为通过β-断裂或氢原子转移过程形成多样化且有价值的烷基自由基的有效方法。烷基自由基物种可以进一步被α-三氟甲基烯烃捕获，构建一系列偕二氟烯烃。