(E)-(2-methylpent-3-ene-1,3-diyldisulfonyl)dibenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-(2-methylpent-3-ene-1,3-diyldisulfonyl)dibenzene
• 英文别名: [(E)-3-(benzenesulfonyl)-2-methylpent-3-enyl]sulfonylbenzene
• 化学式: C₁₈H₂₀O₄S₂
• 分子量: 364.486
• InChiKey: HKZXLXDNINXRMJ-JFQJCAQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  85
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  烯丙基苯砜 在 potassium tert-butylate 、 甲氧苯胺 作用下， 以 甲苯 为溶剂， 反应 15.0h， 以30%的产率得到(E)-(2-methylpent-3-ene-1,3-diyldisulfonyl)dibenzene
  参考文献：
  名称：

  铜催化烯丙基砜与芳香胺的区域选择性加氢胺化

  摘要：

  描述了末端或γ-取代的烯丙基砜与芳族胺的高度区域选择性铜催化的加氢胺化反应。N-杂环卡宾-铜配合物和KO t- Bu的组合在促进温和反应条件下的选择性胺化中起重要作用。这种催化反应可耐受各种官能团，并能够以高收率（高达98％）和> 98％的区域选择性高效合成新型和通用的功能化β-氨基砜。

  DOI：

  10.1002/bkcs.12264

文献信息

• Proazaphosphatrane P(RNCH2CH2)3N (R=Me,i-Pr)-Catalyzed Isomerization of Allylaromatics, Allyl Phenyl Sulfide, Allyl Phenyl Sulfone, andbis-Allylmethylene Double Bond-Containing Compounds
  作者：Zhengkun Yu、Shenggang Yan、Guangtao Zhang、Wei He、Liandi Wang、Yu Li、Fanlong Zeng

  DOI：10.1002/adsc.200505224

  日期：2006.1

  Using a proazaphosphatrane catalyst, P(RNCH2CH2)3N (R=Me, i-Pr), allylaromatics and allyl phenyl sulfide were selectively isomerized to the corresponding vinyl isomers in yields up to >99% in CH3CN at 40 °C. Efficient transformation of allyl phenyl sulfone at ambient temperature afforded an isomerization/dimerization product in >95% yield. Conjugation of bis-allylmethylene double bond-containing compounds

  使用原氮杂磷杂环戊烷催化剂，将P（RNCH 2 CH 2）3 N（R = Me，i- Pr），烯丙基芳烃和烯丙基苯硫醚选择性异构化为相应的乙烯基异构体，在40° C的CH 3 CN中收率最高> 99％℃。在环境温度下烯丙基苯基砜的有效转化以> 95％的收率得到异构化/二聚产物。含双烯丙基亚甲基双键的化合物的共轭可得到相应的顺式，顺式-9,12-十八碳烯醇及其甲基醚的共轭异构体，收率最高可达97％，并且三甲基甲硅烷基的催化反应可制得甲硅烷基化/共轭产物。的以太顺式，顺式-9，12-十八碳烯基醇。基于在反应条件下在CD 3 CN或CH 3 CN中的1 H和31 P NMR监测的反应，讨论了反应机理。
• <scp>Copper‐catalyzed</scp> Regioselective Hydroaminations of Allylic Sulfones With Aromatic Amines
  作者：Kundo Kim、Soohong Cho、Subin Park、Yunmi Lee

  DOI：10.1002/bkcs.12264

  日期：2021.4

  regioselective copper‐catalyzed hydroaminations of terminal or γ‐substituted allylic sulfones with aromatic amines is described. The combination of an N‐heterocyclic carbene‐copper complex and KOt‐Bu plays an important role in promoting selective amination under mild reaction conditions. This catalytic reaction tolerates a wide range of functional groups and enables the efficient syntheses of new and versatile

  描述了末端或γ-取代的烯丙基砜与芳族胺的高度区域选择性铜催化的加氢胺化反应。N-杂环卡宾-铜配合物和KO t- Bu的组合在促进温和反应条件下的选择性胺化中起重要作用。这种催化反应可耐受各种官能团，并能够以高收率（高达98％）和> 98％的区域选择性高效合成新型和通用的功能化β-氨基砜。
• Catalytic Dimerization of Allyl Phenyl Sulfone in the Presence of a Proazaphosphatrane Catalyst
  作者：Zhengkun Yu、John G. Verkade

  DOI：10.1002/adsc.200303211

  日期：2004.4

  In the presence of a proazaphosphatrane catalyst P(RNCH2CH2)3N, allyl phenyl sulfone readily dimerizes to give the product shown, for which only incomplete and inconclusive data exist in the literature. The dimer was shown from 1H NMR spectral considerations to have the E configuration.

  在原氮杂磷杂环戊烷催化剂P（RNCH 2 CH 2）3 N存在下，烯丙基苯基砜容易二聚而得到所示产物，文献中仅存在不完全和不确定的数据。从1 H NMR光谱考虑表明该二聚体具有E构型。
• Efficient electrocatalytic addition reactions of allyl phenyl sulfone to electron deficient alkenes
  作者：Greg A.N. Felton、Nathan L. Bauld

  DOI：10.1016/j.tet.2005.01.125

  日期：2005.4

  The use of tetraalkylammonium salts as electrolytes has been found to allow the formation of electrogenerated bases of especially high reactivity. Such conditions allow allyl phenyl sulfone to undergo addition to a variety of electron deficient vinyl and propenyl compounds (sulfone, ketone, nitrile, and ester). The additions are catalyzed by electrogenerated bases derived from the reactant itself, rather than via an added pro-base. The nature of the substrate molecule is seen to affect which type of product is formed, leading to an interplay between addition to 1 mol of substrate or to 2 mol of substrate. Yields of 1: 1 adducts range from 6 to 81%, while yields of 1:2 adducts range from 57 to 96%. (c) 2005 Elsevier Ltd. All rights reserved.
• KO <i>t</i> ‐Bu‐Catalyzed Chemo‐ and Regioselective Hydroamination of Allylic Sulfones with Indoles
  作者：Kundo Kim、Subin Park、Yunmi Lee

  DOI：10.1002/ejoc.202001394

  日期：2021.1.8

  A highly chemo‐ and regioselective hydroamination of β,γ‐unsaturated sulfones with indoles using a KOt‐Bu catalyst is described. A series of β‐indolyl sulfones was easily obtained in good to excellent yields under simple and mild reaction conditions.

  描述了使用KO t- Bu催化剂与吲哚进行β，γ-不饱和砜的高度化学和区域选择性加氢胺化反应。在简单温和的反应条件下，可以轻松获得一系列β-吲哚基砜，收率好至极好。