N-(m-chlorophenyl)-3-phenylpropylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(m-chlorophenyl)-3-phenylpropylamine
• 英文别名: 3-chloro-N-(3-phenylpropyl)aniline
• 化学式: C₁₅H₁₆ClN
• mdl: MFCD11117507
• 分子量: 245.752
• InChiKey: WZLBWGPMQOBJCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-苯丙醇 、 3-氯苯胺 在 aluminum (III) chloride 作用下， 以 均三甲苯 为溶剂， 反应 4.0h， 以76%的产率得到N-(m-chlorophenyl)-3-phenylpropylamine
  参考文献：
  名称：

  Direct N-alkylation of amines with alcohols using AlCl3 as a Lewis acid

  摘要：

  A substitution reaction of amines with alcohols for N-alkylated amines has been developed using inexpensive AlCl3 without any ligand or additive. Either aromatic or aliphatic amines and primary or secondary alcohols perform the AlCl3-mediated reaction smoothly to afford various N-alkylated amines in satisfactory yields. (C) 2014 Zhi-Zhen Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2014.07.006

文献信息

• Direct N-alkylation of amines with alcohols using AlCl3 as a Lewis acid
  作者：Ya-Qiong Li、Yun-Bin Chen、Zhi-Zhen Huang

  DOI：10.1016/j.cclet.2014.07.006

  日期：2014.12

  A substitution reaction of amines with alcohols for N-alkylated amines has been developed using inexpensive AlCl3 without any ligand or additive. Either aromatic or aliphatic amines and primary or secondary alcohols perform the AlCl3-mediated reaction smoothly to afford various N-alkylated amines in satisfactory yields. (C) 2014 Zhi-Zhen Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.