亚铁甘氨酸硫酸盐

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 亚铁甘氨酸硫酸盐
• 英文名称: 2-aminoacetate;hydron;iron(2+);sulfate
• 化学式: C4H10FeN2O8S
• 分子量: 302.04
• InChiKey: YJYOLOWXCPIBSY-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -5.73
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  221
• 氢给体数：
  4
• 氢受体数：
  10

ADMET

毒理性

• 毒性总结

急性铁过量的症状可以分为四个阶段。第一阶段，摄入后六小时内，主要症状是呕吐和腹泻。其他症状包括低血压、心动过速和中枢神经系统抑制，从嗜睡到昏迷不等。第二阶段可能在摄入后6-24小时发生，特点是暂时缓解。第三阶段，胃肠道症状再次出现，伴有休克、代谢性酸中毒、昏迷、肝细胞坏死和黄疸、低血糖、肾衰竭和肺水肿。第四阶段可能在摄入后几周内发生，特点是胃肠道梗阻和肝脏损伤。在儿童中，每公斤体重75毫克被认为是极其危险的。每公斤体重30毫克的剂量可能导致毒性症状。估计的致死剂量从每公斤体重180毫克及以上。血清铁浓度达到每毫升5微克或更高与中到重度中毒有关。

Acute iron overdosage can be divided into four stages. In the first stage, which occurs up to six hours after ingestion, the principal symptoms are vomiting and diarrhea. Other symptoms include hypotension, tachycardia and CNS depression ranging from lethargy to coma. The second phase may occur at 6-24 hours after ingestion and is characterized by a temporary remission. In the third phase, gastrointestinal symptoms recur accompanied by shock, metabolic acidosis, coma, hepatic necrosis and jaundice, hypoglycemia, renal failure and pulmonary edema. The fourth phase may occur several weeks after ingestion and is characterized by gastrointestinal obstruction and liver damage. In a young child, 75 milligrams per kilogram is considered extremely dangerous. A dose of 30 milligrams per kilogram can lead to symptoms of toxicity. Estimates of a lethal dosage range from 180 milligrams per kilogram and upwards. A peak serum iron concentration of five micrograms or more per ml is associated with moderate to severe poisoning in many.

来源:DrugBank

吸收、分配和排泄

• 吸收

吸收效率取决于盐的形式、给药量、给药方案和铁储备的大小。铁储备正常的受试者可以吸收10%到35%的铁剂量。而缺铁的人可能会吸收高达95%的铁剂量。

The efficiency of absorption depends on the salt form, the amount administered, the dosing regimen and the size of iron stores. Subjects with normal iron stores absorb 10% to 35% of an iron dose. Those who are iron deficient may absorb up to 95% of an iron dose.

来源:DrugBank