(5,6-dimethyl-1H-benzo[d]imidazol-1-yl)(o-tolyl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: (5,6-dimethyl-1H-benzo[d]imidazol-1-yl)(o-tolyl)methanone
• 英文别名: (5,6-Dimethylbenzimidazol-1-yl)-(2-methylphenyl)methanone
• 化学式: C₁₇H₁₆N₂O
• 分子量: 264.327
• InChiKey: RJYQIGXVIZCBAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5,6-二甲基苯并咪唑 、 2-甲基苯甲醛 在 二叔丁基过氧化物 作用下， 以 乙酸乙酯 为溶剂， 反应 15.0h， 以70%的产率得到(5,6-dimethyl-1H-benzo[d]imidazol-1-yl)(o-tolyl)methanone
  参考文献：
  名称：

  Metal-free cross-dehydrogenative coupling of benzimidazoles with aldehydes to N-acylbenzimidazoles

  摘要：

  A novel and direct cross-dehydrogenative coupling (CDC) between benzimidazoles with aldehydes promoted by di-tert-butyl peroxide (DTBP) was developed. The reactions generated the corresponding N-acylbenzimidazoles in good yields under metal-free conditions. This method has broad substrate scope and high efficiency. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.07.009

文献信息

• Metal-free cross-dehydrogenative coupling of benzimidazoles with aldehydes to N-acylbenzimidazoles
  作者：Lin Yu、Min Wang、Lei Wang

  DOI：10.1016/j.tet.2014.07.009

  日期：2014.9

  A novel and direct cross-dehydrogenative coupling (CDC) between benzimidazoles with aldehydes promoted by di-tert-butyl peroxide (DTBP) was developed. The reactions generated the corresponding N-acylbenzimidazoles in good yields under metal-free conditions. This method has broad substrate scope and high efficiency. (C) 2014 Elsevier Ltd. All rights reserved.