(2S)-2-methyl-5-(methylamino)-5-oxopentanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2S)-2-methyl-5-(methylamino)-5-oxopentanoic acid
• 化学式: C₇H₁₃NO₃
• 分子量: 159.18
• InChiKey: XNRCSSAZPTVAKK-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP3636807A1

  公开（公告）日：2020-04-15

  The present inventors have found that when screening for cyclic peptide compounds that can specifically bind to a target molecule, the use of a library including cyclic peptide compounds having a long side chain in the cyclic portion can improve the hit rate for cyclic peptide compounds that can specifically bind to the target molecule. Meanwhile, the present inventors have found that tryptophan and tyrosine residues, which have conventionally been used in oral low molecular-weight pharmaceuticals and are amino acid residues having an indole skeleton or a hydroxyphenyl group, are not suitable for peptides intended to attain high membrane permeability.

  本发明人发现，在筛选能与目标分子特异性结合的环肽化合物时，使用包括环状部分具有长侧链的环肽化合物库，可以提高能与目标分子特异性结合的环肽化合物的命中率。同时，本发明者发现色氨酸和酪氨酸残基不适合用于旨在获得高膜渗透性的肽，这两种残基通常用于口服低分子量药物，是具有吲哚骨架或羟基苯基的氨基酸残基。
• Conjugated polymer-based nanoprobe and preparation method and application thereof
  申请人：SHANGHAI JIAO TONG UNIVERSITY

  公开号：US10702612B2

  公开（公告）日：2020-07-07

  Disclosed is a conjugated polymer-based nanoprobe, including a fluorescent conjugated polymer, a surface ligand, a target molecule, a near-infrared fluorescent dye and optionally a gadolinium-containing magnetic resonance contrast agent. This application also discloses a method for preparing the conjugated polymer-based nanoprobe, including: adding raw materials to an organic solvent followed by ultrasonication to obtain a mixture; and adding the mixture to ultrapure water and continuously ultrasonicating the reaction mixture. The conjugated polymer-based nanoprobe can be applied in a combined molecular imaging technique of near infrared fluorescence imaging, photoacoustic imaging and magnetic resonance imaging to effectively recognize metastatic lymph nodes and normal lymph nodes, and it can be retained in the metastatic lymph nodes for a long time, meeting the requirements for long-term observation. Moreover, the near-infrared fluorescent conjugated polymer-based nanoprobe can generate reactive oxygen under irradiation, which is suitable for the photodynamic treatment of tumors.

  本申请公开了一种共轭聚合物基纳米探针，包括荧光共轭聚合物、表面配体、目标分子、近红外荧光染料和可选的含钆磁共振造影剂。本申请还公开了一种制备共轭聚合物基纳米探针的方法，包括：将原材料加入有机溶剂中，然后超声处理，得到混合物；将混合物加入超纯水中，持续超声处理反应混合物。该共轭聚合物基纳米探针可应用于近红外荧光成像、光声成像和磁共振成像的联合分子成像技术，有效识别转移淋巴结和正常淋巴结，并可在转移淋巴结中长期保留，满足长期观察的要求。此外，基于近红外荧光共轭聚合物的纳米探针在照射下可产生活性氧，适用于肿瘤的光动力治疗。