N-(3-hydroxypropyl)-N-methylethanesulfonamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N-(3-hydroxypropyl)-N-methylethanesulfonamide
• 化学式: C₆H₁₅NO₃S
• 分子量: 181.26
• InChiKey: VJTZONYKNBVOCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] SUBSTRATE SELECTIVE INHIBITORS OF INSULIN-DEGRADING ENZYME (IDE) AND USES THEREOF<br/>[FR] INHIBITEURS SÉLECTIFS DE SUBSTRATS D'ENZYME DÉGRADANT L'INSULINE (IDE) ET UTILISATIONS ASSOCIÉES
  申请人：HARVARD COLLEGE

  公开号：WO2016172631A2

  公开（公告）日：2016-10-27

  Provided herein are compounds of Formulae (RL), (I), (II), (III), (IV), and (V), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, prodrugs, and isotopically labeled derivatives thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment of metabolic disorders (e.g., diabetes, hyperglycemia, impaired glucose tolerance, insulin resistance, obesity). The compound are useful as substrate selective inhibitors of insulin-degrading enzyme (IDE).