ethyl N-cyclohexyl-N-ethylglycinate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl N-cyclohexyl-N-ethylglycinate
• 英文别名: ethyl 2-[cyclohexyl(ethyl)amino]acetate
• 化学式: C₁₂H₂₃NO₂
• mdl: MFCD11180534
• 分子量: 213.32
• InChiKey: RDLANXWJSTTZAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.916
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-乙基环己胺 、 溴乙酸乙酯 在 potassium carbonate 作用下， 以 水 为溶剂， 反应 20.0h， 生成 ethyl N-cyclohexyl-N-ethylglycinate
  参考文献：
  名称：

  WO2006/48750

  摘要：

  公开号：

文献信息

• NOVEL COMPOUNDS OF SUBSTITUTED AND UNSUBTITUTED ADAMANTYL AMIDES
  申请人：Cheng Hengmiao

  公开号：US20090093463A1

  公开（公告）日：2009-04-09

  The present invention relates to compounds with the formula (I) or a pharmaceutically acceptable salt thereof: The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of 11-β-hsd-1, the method comprising administering to a mammal an effective amount of a compound of formula (I).

  本发明涉及公式(I)的化合物或其药学上可接受的盐：该发明还涉及包含公式(I)化合物的制药组合物，以及治疗通过调节11-β-hsd-1介导的疾病的方法，该方法包括向哺乳动物投与公式(I)化合物的有效量。
• HEAT-EXPANDABLE MICROSPHERE, PROCESS FOR PRODUCING THE SAME, AND USE
  申请人：MATSUMOTO YUSHI-SEIYAKU CO., LTD.

  公开号：EP1952881A1

  公开（公告）日：2008-08-06

  The heat-expandable microspheres comprise a shell of thermoplastic resin and a blowing agent encapsulated therein having a boiling point not higher than the softening point of the thermoplastic resin, have a maximum expanding ratio not lower than 50 times, and are thermally expanded into hollow particulates having a repeated-compression durability not lower than 75 percent. The method of producing the heat-expandable microspheres comprises the steps of dispersing an oily mixture containing a polymerizable component and the blowing agent in an aqueous dispersing medium containing a specific water-soluble compound and polymerizing the polymerizable component contained in the oily mixture.

  热膨胀微球由热塑性树脂外壳和封装在其中的发泡剂组成，发泡剂的沸点不高于热塑性树脂的软化点，最大膨胀比不低于 50 倍，经热膨胀成空心颗粒，重复压缩耐久性不低于 75%。生产热膨胀微球的方法包括以下步骤：在含有特定水溶性化合物的水性分散介质中分散含有可聚合组分和发泡剂的油性混合物，并聚合油性混合物中所含的可聚合组分。
• NOVEL COMPOUNDS OF SUBSTITUTED AND UNSUBSTITUTED ADAMANTYL AMIDES
  申请人：Pfizer, Inc.

  公开号：EP1812407A2

  公开（公告）日：2007-08-01
• PROCESS FOR PRODUCING HEAT-EXPANDABLE MICROSPHERES
  申请人：MATSUMOTO YUSHI-SEIYAKU CO., LTD.

  公开号：EP1952881B1

  公开（公告）日：2017-01-18
• HEAT-EXPANDABLE MICROSPHERES, METHOD FOR PRODUCING THE SAME, AND APPLICATION THEREOF
  申请人：Masuda Toshiaki

  公开号：US20090149559A1

  公开（公告）日：2009-06-11

  Heat-expandable microspheres include a shell of thermoplastic resin and a blowing agent encapsulated therein having a boiling point not higher than the softening point of the thermoplastic resin, have a maximum expanding ratio not lower than 50 times, and are thermally expanded into hollow particulates having a repeated-compression durability not lower than 75 percent. The method of producing the heat-expandable microspheres includes the steps of dispersing an oily mixture containing a polymerizable component and the blowing agent in an aqueous dispersing medium containing a specific water-soluble compound and polymerizing the polymerizable component contained in the oily mixture.