3-(4-(dimethylamino)phenyl)-2-methylpropanal

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-(dimethylamino)phenyl)-2-methylpropanal
• 英文别名: 3-[4-(Dimethylamino)phenyl]-2-methylpropanal；3-[4-(dimethylamino)phenyl]-2-methylpropanal
• 化学式: C₁₂H₁₇NO
• 分子量: 191.273
• InChiKey: FFJJFYWJLQNJLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基丙烯醛 、 N,N-二甲基苯胺 在 C₃₁H₄₁AlF₆N₂O₆S₂*C₂₄H₁₂BCl₈^(1-)*Na⁽¹⁺⁾ 作用下， 以 二氯甲烷-D2 为溶剂， 反应 24.0h， 以43%的产率得到3-(4-(dimethylamino)phenyl)-2-methylpropanal
  参考文献：
  名称：

  β-二酮支持的铝配合物催化的迈克尔加成反应

  摘要：

  β-二甲双胍负载的双硫铝铝络合物（Dip LAl（OTf）2 ·Na [BAr Cl 4 ]; Dip L = CH（CMe）2（NC 6 H 3 - i Pr 2）2 ; Tf = O 2 SCF 3； Ar Cl = 3,5-Cl 2 -C 6 H 3）已被证实是迈克尔加成反应的有效路易斯酸催化剂，涉及许多富电子（杂）芳族底物和几种α，β-不饱和羰基化合物。在绝大多数尝试的迈克尔反应中，就反应时间和温度，催化剂负载量，分离的产物收率和/或选择性而言，对于相同的转化，我们的催化体系明显优于目前使用的方法。

  DOI：

  10.1021/acs.joc.8b00434

文献信息

• B(C₆F₅)₃-Catalyzed Michael Reactions: Aromatic C–H as Nucleophiles
  作者：Wu Li、Thomas Werner

  DOI：10.1021/acs.orglett.7b00720

  日期：2017.5.19

  The Michael reaction is a widely used reaction for the C–C coupling of electron-poor olefins and C(sp3)–H pronucleophiles. Herein we report the Michael reaction between alkenes and aromatic as well as heteroaromatic compounds as aromatic C(sp2)–H nucleophiles under mild conditions. The reaction is catalyzed by readily available Lewis acidic B(C6F5)3 and proceeds with high regioselectivity for a wide

  迈克尔反应是贫电子烯烃与C（sp 3）-H前亲核试剂的C-C偶联反应中广泛使用的反应。在这里，我们报道了在温和条件下烯烃与芳香族以及杂芳香族化合物（如芳香族C（sp 2）–H亲核体）之间的迈克尔反应。该反应被易得的路易斯酸性B（C 6 F 5）3催化，并在较大的底物范围内以高区域选择性进行。
• RUBBER COMPOSITION AND TIRE
  申请人：Bridgestone Corporation

  公开号：EP3406663A1

  公开（公告）日：2018-11-28

  A rubber composition has: at least three types of diene polymers forming a plurality of polymer phases immiscible with each other; and silica, wherein: a diene polymer (B), of which glass transition temperature (Tg) is neither the highest nor the lowest among the diene polymers each having content of ≥ 10% by mass with respect to the total mass of the diene polymers, has been modified by a compound containing silicon atom; the diene polymer (B) satisfies formula (i) shown below: St+Vi/2≤33 (In the formula, "St" represents content of bonded styrene (mass %) of the diene polymer (B) and "Vi" represents vinyl bond content (mass %) of a conjugated diene compound part of the diene polymer (B)); and the silica has content of ≥ 25 parts by mass with respect to the total mass or 100 parts by mass of the diene polymers.

  一种橡胶组合物具有：至少三种类型的二烯聚合物，形成多个彼此不相溶的聚合物相；以及白炭黑，其中：二烯聚合物（B）的玻璃化转变温度（Tg）在二烯聚合物中既不是最高的，也不是最低的，每种二烯聚合物的玻璃化转变温度（Tg）在二烯聚合物总质量中的含量≥10%，已被含硅原子的化合物改性；二烯聚合物（B）满足下式(i)：St+Vi/2≤33（式中，"St "表示二烯聚合物（B）中键合苯乙烯的含量（质量百分 比），"Vi "表示二烯聚合物（B）中共轭二烯化合物部分的乙烯基键含量（质量百分 比））；相对于二烯聚合物的总质量或 100 质量份，二氧化硅的含量≥25 质量份。
• Rubber composition and tire
  申请人：BRIDGESTONE CORPORATION

  公开号：US10611899B2

  公开（公告）日：2020-04-07

  A rubber composition, capable of improving both on-ice performance and wear resistance of a tire, contains at least one type of diene polymer, silica, and a resin, wherein: 5 MP≤storage elastic modulus (E′) of the rubber composition at −20° C.≤10 MPa; storage elastic modulus (E′) at −20° C. and loss tangent (tan δ) at −20° C. of the rubber composition satisfy formula (1) below; and a mass ratio of content (parts by mass) of the silica with respect to content (parts by mass) of the resin, or silica content/resin content, is in the range of 1.00 to 4.00. 0.02×(E′−20° C.)+0.25≤(tan δ−20° C.)≤0.65  (1) In the formula, (E′−20° C.) represents storage elastic modulus (MPa) of the rubber composition at −20° C. and (tan δ−20° C.) represents loss tangent of the rubber composition at −20° C.

  一种能改善轮胎冰上性能和耐磨性的橡胶组合物，含有至少一种二烯聚合物、白炭黑和树脂，其中：5MP≤橡胶组合物在-20° C.的储存弹性模量（E′）≤10MPa；橡胶组合物在-20° C.的储存弹性模量（E′）和在-20° C.的损耗正切（tan δ）满足下式（1）；白炭黑含量（质量份数）与树脂含量（质量份数）的质量比，或白炭黑含量/树脂含量在 1.00 至 4.00 之间。 0.02×(E′-20°C)+0.25≤(tan δ-20°C)≤0.65 (1) 式中，(E′-20° C.)表示-20° C 时橡胶成分的储存弹性模量（兆帕），(tan δ-20° C.)表示-20° C 时橡胶成分的损耗正切。
• METHOD FOR MANUFACTURING MODIFIED POLYMER, MODIFIED POLYMER, RUBBER COMPOSITION AND TIRE
  申请人：BRIDGESTONE CORPORATION

  公开号：US20190077891A1

  公开（公告）日：2019-03-14

  The present disclosure provides a method for manufacturing with high productivity a modified polymer equivalent to the prior art blend of a modified polymer for matrix of a rubber composition and the low-molecular weight polymer. Specifically, a method for manufacturing a modified polymer, including continuously supplying a raw material monomer containing at least conjugated diene compound, a polymerization initiator containing lithium, 1,2-butadiene and a modification agent into a flow-through reactor, causing the raw material monomer to be continuously polymerized to generate polymer and also causing a portion of the polymer thus generated to be modified with the modification agent, is characterized in that: the polymerization and the modification are carried out at temperature equal to 110° C. or higher; and a mole ratio (1,2-Bd/Li) of the 1,2-butadiene (1,2-Bd) with respect to lithium (Li) of the polymerization initiator containing lithium is set to be 0.37 or less.