2-(hydroxyamino)-1-(thiophen-2-yl)propan-1-one oxime

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(hydroxyamino)-1-(thiophen-2-yl)propan-1-one oxime
• 英文别名: N-[2-(hydroxyamino)-1-thiophen-2-ylpropylidene]hydroxylamine
• 化学式: C₇H₁₀N₂O₂S
• 分子量: 186.235
• InChiKey: YRMIAEIJPCKYMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  93.1
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(hydroxyamino)-1-(thiophen-2-yl)propan-1-one oxime 在 溶剂黄146 作用下， 以 甲醇 、 水 为溶剂， 反应 27.0h， 生成 4,4′-dimethyl-5,5′-di(thiophen-2-yl)-1H,1'H-2,2′-biimidazole-1,1′-diol
  参考文献：
  名称：

  5,5'-二芳基-2,2'-联咪唑-1,1'-二醇：与碘甲烷和三苯基膦的反应

  摘要：

  摘要 用等摩尔量的甲基碘将5,5'-二芳基-2,2'-联咪唑-1,1'-二醇烷基化，得到相应的N-甲基衍生物，然后与3当量的甲基碘反应，得到烷基化产物在氮原子和两个羟基上。5,5'-二芳基-1- ħ，1' ħ -2,2'-联咪唑，通过治疗用三苯基膦的标题化合物获得。

  DOI：

  10.1134/s1070428020100073

文献信息

• Synthesis of 2-Aroyl(Hetaroyl)-1-Hydroxy- Imidazoles by the Interaction of Alkyl-Aromatic α-Hydroxyaminooximes with Aryl(Hetaryl)Glyoxals
  作者：E. B. Nikolaenkova、A. Ya. Tikhonov、S. A. Amitina、Yu. V. Gatilov

  DOI：10.1007/s10593-014-1523-2

  日期：2014.8

  The interaction of alkylaromatic and alkylheteroaromatic alpha-hydroxyaminooximes with aryl(hetaryl)-glyoxals hydrates produced a new series of 2-aroyl(hetaroyl)-5-aryl(hetaryl)-1-hydroxy-4-methylimid-azoles. The X-ray structural data for 2-benzoyl-5-(4-fluorophenyl)-1-hydroxy-4-methylimidazole are presented.
• Synthesis of substituted 2-(thiophen-2-yl)-1H-imidazol-1-ols
  作者：I. A. Os’kina、A. Ya. Tikhonov

  DOI：10.1134/s1070428017020166

  日期：2017.2

  Substituted 2-(thiophen-2-yl)-1H-imidazol-1-ols were synthesized by cyclization of the corresponding alpha-thienyl nitrones in alkaline medium. alpha-Thienyl nitrones were obtained by reaction of N-(1-hydroxyimine-1-R-propan-2-yl)hydroxylamines with thiophene-2-carbaldehyde in methanol. At boiling alpha-thienyl nitrones in methanol in the presence of sodium methylate 5-aryl(hetaryl)-2-(thiophen-2-yl)-1H-imidazol-1-ols are formed chemoselectively.
• 5,5′-Diaryl-2,2′-biimidazole-1,1′-diols: Reactions with Methyl Iodide and Triphenylphosphine
  作者：I. A. Osʼkina、A. Ya. Tikhonov

  DOI：10.1134/s1070428020100073

  日期：2020.10

  Abstract The alkylation of 5,5′-diaryl-2,2′-biimidazole-1,1′-diols with an equimolar amount of methyl iodide gave the corresponding N-methyl derivatives, and the reaction with 3 equiv of methyl iodide afforded alkylation products at the nitrogen atom and both hydroxy groups. 5,5′-Diaryl-1H,1′H-2,2′-biimidazoles were obtained by treatment of the title compounds with triphenylphosphine.

  摘要 用等摩尔量的甲基碘将5,5'-二芳基-2,2'-联咪唑-1,1'-二醇烷基化，得到相应的N-甲基衍生物，然后与3当量的甲基碘反应，得到烷基化产物在氮原子和两个羟基上。5,5'-二芳基-1- ħ，1' ħ -2,2'-联咪唑，通过治疗用三苯基膦的标题化合物获得。