rac-1-hexadecyl-2-hexadec-9-enyl-3-phosphoglycerol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: rac-1-hexadecyl-2-hexadec-9-enyl-3-phosphoglycerol
• 英文别名: rac-1-hexadecyl-2-hexadec-9-encyl-3-phosphoglycerol；2,3-Dihydroxypropyl (2-hexadec-9-enoxy-3-hexadecoxypropyl) hydrogen phosphate；2,3-dihydroxypropyl (2-hexadec-9-enoxy-3-hexadecoxypropyl) hydrogen phosphate
• 化学式: C₃₈H₇₇O₈P
• 分子量: 692.998
• InChiKey: KRBGKFWGBOLRQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12
• 重原子数：
  47
• 可旋转键数：
  39
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  丙酮缩甘油 在 三乙胺 、 三氯氧磷 、 sodium carbonate 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以43%的产率得到rac-1-hexadecyl-2-hexadec-9-enyl-3-phosphoglycerol
  参考文献：
  名称：

  WO2008/11559

  摘要：

  公开号：

文献信息

• SYNTHETIC ANALOGS OF LUNG SURFACTANT PROTEIN SP-C AND THEIR USE
  申请人：Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

  公开号：EP3459556A1

  公开（公告）日：2019-03-27

  The present invention relates to synthetic lung surfactant compositions that include a novel surface active peptide and a phospholipid, including phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, naturally occurring phospholipids, or a combination thereof. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue and to deliver therapeutic agents are also disclosed. Although preferred embodiments have been depicted and described in detail herein, it will be apparent to those skilled in the relevant art that various modifications, additions, substitutions, and the like can be made without departing from the spirit of the invention and these are therefore considered to be within the scope of the invention as defined in the claims which follow.

  本发明涉及合成肺表面活性剂组合物，其中包括一种新型表面活性肽和一种磷脂，包括抗磷脂酶磷酰甘油衍生物、抗磷脂酶磷酰胆碱衍生物、天然磷脂或其组合。还公开了本发明的表面活性物质组合物用于治疗内源性表面活性物质功能障碍或缺乏的肺组织以及递送治疗剂的用途。 尽管本文已详细描述了优选的实施方案，但对于那些熟悉相关技术的人来说，显然可以在不脱离本发明精神的前提下进行各种修改、添加、替换等，因此这些都被认为是在后面的权利要求书所定义的本发明范围之内。
• SP-B and SP-C peptides, synthetic lung surfactants, and use thereof
  申请人：LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER

  公开号：US10358465B2

  公开（公告）日：2019-07-23

  The present invention relates to synthetic lung surfactant compositions that include a novel surface active peptide and a phospholipid, including phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, naturally occurring phospholipids, or a combination thereof. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue and to deliver therapeutic agents are also disclosed.

  本发明涉及合成肺表面活性剂组合物，其中包括一种新型表面活性肽和一种磷脂，包括抗磷脂酶磷酰甘油衍生物、抗磷脂酶磷酰胆碱衍生物、天然磷脂或其组合。还公开了本发明的表面活性物质组合物用于治疗内源性表面活性物质功能障碍或缺乏的肺组织以及递送治疗剂的用途。
• Synthesis and surface activity of diether-linked phosphoglycerols: Potential applications for exogenous lung surfactants
  作者：Robert H. Notter、Zhongyi Wang、Zhengdong Wang、Jason A. Davy、Adrian L. Schwan

  DOI：10.1016/j.bmcl.2006.09.083

  日期：2007.1

  The synthesis of three phosphoglycerols is described, one of which contains the previously unknown phosphonoglycerol headgroup. The surface tension-lowering capabilities of synthetic lung surfactant mixtures containing the PG analogs wore measured on the pulsating bubble surfactometer and compared to known controls. The PG-containing mixtures exhibited superior surface tension-lowering properties indicating the significant potential of these analogs as components in synthetic exogenous lung surfactants. (c) 2006 Elsevier Ltd. All rights reserved.
• SYNTHETIC LUNG SURFACTANT AND USE THEREOF
  申请人：University of Rochester Medical Center

  公开号：EP2049554A2

  公开（公告）日：2009-04-22
• NOVEL SP-B&SP-C PEPTIDES, SYNTHETIC LUNG SURFACTANTS, AND USE THEREOF
  申请人：University of Rochester

  公开号：EP2812018A2

  公开（公告）日：2014-12-17