cis-N-benzyl-3-bromomethyl-4-(2,2,2-trichloroethyl)pyrrolidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cis-N-benzyl-3-bromomethyl-4-(2,2,2-trichloroethyl)pyrrolidine
• 英文别名: (3R,4S)-1-benzyl-3-(bromomethyl)-4-(2,2,2-trichloroethyl)pyrrolidine
• 化学式: C₁₄H₁₇BrCl₃N
• 分子量: 385.559
• InChiKey: GLIFMGHRMQFPKF-OLZOCXBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  三氯溴甲烷 、 N,N-di-2-propenylbenzylamine 在 potassium acetate 、 manganese(II) acetate 、 氰乙酸甲酯 作用下， 以 溶剂黄146 为溶剂， 反应 1.5h， 生成 trans-N-benzyl-3-bromomethyl-4-(2,2,2-trichloroethyl)pyrrolidine 、 cis-N-benzyl-3-bromomethyl-4-(2,2,2-trichloroethyl)pyrrolidine
  参考文献：
  名称：

  A Straightforward Synthesis of [3.3.0]Bicyclic Compounds

  摘要：

  cis-3-Aza- and 3-Oxo-bicyclo[3.3.0]octane were prepared in two steps from the corresponding 1,6-dienes.

  DOI：

  10.1080/00397919508015487

文献信息

• A Straightforward Synthesis of [3.3.0]Bicyclic Compounds
  作者：I. Lachaise、K. Nohair、M. Hakiki、J. Y. Nédélec

  DOI：10.1080/00397919508015487

  日期：1995.11

  cis-3-Aza- and 3-Oxo-bicyclo[3.3.0]octane were prepared in two steps from the corresponding 1,6-dienes.
• A Room Temperature Kharasch Reaction Catalyzed by Pd(0) in a Heterogeneous Aqueous System
  作者：Dai Motoda、Hidenori Kinoshita、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1002/1615-4169(200206)344:3/4<261::aid-adsc261>3.0.co;2-7

  日期：2002.6

  The palladium-catalyzed Kharasch reaction of alkenes and alkynes is enhanced by the use of a heterogeneous aqueous system, without the use of hydrophilic co-solvents or phase transfer catalysts. The Pd(0)-catalyzed reaction of terminal alkenes with bromotrichloromethane in water goes to completion within 2 h at room temperature, whereas no reaction occurs in benzene otherwise under the same conditions. The Pd(0) catalyst in aqueous me la a so effects the radical addition of iodoperfluoroalkanes toward terminal alkenes and alkynes at room temperature.