(Z)-2-(methylthio)-1-(butyltelluro)-1-phenylethene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-2-(methylthio)-1-(butyltelluro)-1-phenylethene
• 英文别名: [(Z)-1-butyltellanyl-2-methylsulfanylethenyl]benzene
• 化学式: C₁₃H₁₈STe
• 分子量: 333.952
• InChiKey: OBRBEDFBHPCJNI-QBFSEMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.27
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (碘乙炔基)苯 、 (Z)-2-(methylthio)-1-(butyltelluro)-1-phenylethene 在 copper(l) iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以40%的产率得到2-[(Z)-2-methylsulfanyl-1-phenylethenyl]tellanylethynylbenzene
  参考文献：
  名称：

  Csp3-tellurium copper cross-coupling: synthesis of alkynyl tellurides a novel class of antidepressive-like compounds

  摘要：

  We present here the results on the synthesis of functionalized alkynyl tellurides using the reaction of vinyl, alkynyl, and aryl tellurides with several alkynyl iodides catalyzed by copper iodide. The reaction proceeded cleanly under mild reaction conditions, at room temperature, in the absence of base and ligand giving alkynyl tellurides in acceptable yields. The obtained compounds 3a-c and 3m-o were screened for antidepressive-like activity using the tail Suspension test (TST) in mice. Compounds 3a-c and 3m-o administered at 10 mg/kg by oral route produced a significant antidepressant-like effect on the TST in mice. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.024

文献信息

• Stereospecific Synthesis of Chalcogenoenynes by Palladium-Catalyzed Cross-Coupling Reaction
  作者：Gilson Zeni、Cristina W. Nogueira、Jesus M. Pena、Cristiane Pilissão、Paulo H. Menezes、Antonio L. Braga、João B. Rocha

  DOI：10.1055/s-2003-37519

  日期：——

  A new methodology for the synthesis of chalcogenoenynes is described. The palladium-catalyzed cross-coupling reaction of 1,2-bis(organanylchalcogeno)-alkenes and 1-alkynes gave the corresponding chalcogenoenynes in 71% to88% yields. Preliminary pharmacologycal tests suggest that chalcogenoenynes may be useful drugs as anti-inflammatory and antinociceptive agents.

  描述了一种合成硫属元素烯的新方法。钯催化的 1,2-双（有机基硫属元素）-烯烃和 1-炔烃的交叉偶联反应以 71% 至 88% 的产率得到相应的硫属元素炔。初步药理学试验表明硫属元素烯可能是有用的药物作为抗炎和镇痛剂。
• Palladium-Catalyzed Negishi Cross-Coupling of Arylzinc Reagents with Functionalized Vinylic Tellurides
  作者：Gilson Zeni、Diego Alves、Ricardo Schumacher、Ricardo Brandão、Cristina Nogueira

  DOI：10.1055/s-2006-939065

  日期：——

  The Negishi cross-coupling reaction of arylzinc chlorides and bromides with functionalized vinylic tellurides in the ­presence of a catalytic amount of PdCl2 in THF at room temperature is described. This cross-coupling reaction is general and permits the synthesis of functionalized substituted alkenes in good yields and high stereoselectivity.

  介绍了芳基氯化锌和溴化物与官能化乙烯基碲在催化量 PdCl2 的存在下于室温下在 THF 中发生的 Negishi 交叉偶联反应。该交叉偶联反应是一种通用反应，能以良好的产率和较高的立体选择性合成官能化取代烯。