2,7-dimethyl-2H-benzo[b][1,4]thiazin-3(4H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 2,7-dimethyl-2H-benzo[b][1,4]thiazin-3(4H)-one
• 英文别名: 2,7-dimethyl-2H-1,4-benzothiazin-3(4H)-one；2,7-dimethyl-4H-1,4-benzothiazin-3-one
• 化学式: C₁₀H₁₁NOS
• 分子量: 193.269
• InChiKey: LRPLNQQOYGQNHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴丙酸乙酯 、 2-氨基-5-甲基苯硫酚 在 potassium fluoride on basic alumina 作用下， 反应 30.0h， 以92%的产率得到2,7-dimethyl-2H-benzo[b][1,4]thiazin-3(4H)-one
  参考文献：
  名称：

  Synergistic promoting effect of ball milling and KF–alumina support for the green synthesis of benzothiazinones

  摘要：

  A solvent-free procedure was developed for the reaction of 2-aminothiophenols with 2-bromoalkanoates, where KF-Al2O3 support and ball milling cooperatively lead to a green and efficient synthesis of several benzothiazinone derivatives in good to excellent yields. The catalyst could be recycled in further reactions while maintaining its activity. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.12.078

文献信息

• Synergistic promoting effect of ball milling and KF–alumina support for the green synthesis of benzothiazinones
  作者：Ali Sharifi、Mohammad Ansari、Hossein Reza Darabi、M. Saeed Abaee

  DOI：10.1016/j.tetlet.2015.12.078

  日期：2016.2

  A solvent-free procedure was developed for the reaction of 2-aminothiophenols with 2-bromoalkanoates, where KF-Al2O3 support and ball milling cooperatively lead to a green and efficient synthesis of several benzothiazinone derivatives in good to excellent yields. The catalyst could be recycled in further reactions while maintaining its activity. (C) 2015 Elsevier Ltd. All rights reserved.