1-(1-phenylethyl)-4-(thiophen-3-yl)-1H-[1,2,3]triazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(1-phenylethyl)-4-(thiophen-3-yl)-1H-[1,2,3]triazole
• 英文别名: 1-(1-Phenylethyl)-4-thiophen-3-yltriazole
• 化学式: C₁₄H₁₃N₃S
• 分子量: 255.343
• InChiKey: QVBYMQVNOOBIRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-乙炔基噻吩 、 苏合香醇 在 copper(II) bis(trifluoromethanesulfonate) 、 铜 叠氮基三甲基硅烷 作用下， 以 硝基甲烷 为溶剂， 反应 6.0h， 以65%的产率得到1-(1-phenylethyl)-4-(thiophen-3-yl)-1H-[1,2,3]triazole
  参考文献：
  名称：

  Regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles via three-component coupling of secondary alcohols, TMSN3 and alkynes

  摘要：

  1.4-Disubstituted 1.2.3-triazoles are obtained in excellent yields via a three-component coupling of secondary alcohols, alkynes and trimethylsilyl azide (TMSN3). This one-pot reaction occurs through in situ generation of an azide from the alcohol and TMSN3, followed by 1,3-dipolar cycloaddition of the terminal alkyne to afford the corresponding disubstituted triazoles. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.06.069

文献信息

• Regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles via three-component coupling of secondary alcohols, TMSN3 and alkynes
  作者：B. Sreedhar、P. Surendra Reddy、V. Rama Krishna

  DOI：10.1016/j.tetlet.2007.06.069

  日期：2007.8

  1.4-Disubstituted 1.2.3-triazoles are obtained in excellent yields via a three-component coupling of secondary alcohols, alkynes and trimethylsilyl azide (TMSN3). This one-pot reaction occurs through in situ generation of an azide from the alcohol and TMSN3, followed by 1,3-dipolar cycloaddition of the terminal alkyne to afford the corresponding disubstituted triazoles. (c) 2007 Elsevier Ltd. All rights reserved.