全氟-(乙基环戊烷) | 374-81-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 中文名称: 全氟-(乙基环戊烷)
• 英文名称: perfluoro-(ethylcyclopentane)
• 英文别名: perfluoroethylcyclopentane；F-1-Ethylcyclopentene；nonafluoro-pentafluoroethyl-cyclopentane；Nonafluor-pentafluoraethyl-cyclopentan；1,1,2,2,3,3,4,4,5-nonafluoro-5-(1,1,2,2,2-pentafluoroethyl)cyclopentane
• CAS: 374-81-2
• 化学式: C₇F₁₄
• 分子量: 350.055
• InChiKey: BNUWKSVIKXVBBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  正庚烷 在 cobalt (III) fluoride 、 氮气 作用下， 生成 全氟-(乙基环戊烷)
  参考文献：
  名称：

  中试植物合成-全氟正庚烷，全氟二甲基环己烷和高沸点碳氟化合物油

  摘要：

  DOI：

  10.1021/ie50447a618

文献信息

• Fluoroolefin condensation catalyzed by aluminum chlorofluoride
  作者：Carl G. Krespan、David A. Dixon

  DOI：10.1016/0022-1139(96)03388-x

  日期：1996.4

  High-fluorine-content aluminum chlorofluoride, as prepared by Cl/F exchange of aluminum chloride with one of a number of organofluorine compounds, is a very active Lewis acid capable of condensing an allylic fluoride with another fluoroolefin at low temperature. In addition to a description of broader scope, details of the selective reaction of hexafluoropropene with tetrafluoroethylene to form F-pentene-2

  通过将氯化铝与多种有机氟化合物之一进行Cl / F交换制得的高氟含量的氯氟化铝是一种非常活泼的路易斯酸，它能够在低温下使烯丙基氟与另一种氟烯烃缩合。除了更广泛的描述外，还介绍了六氟丙烯与四氟乙烯选择性反应生成F-戊烯-2的细节，以及支持多氟烯丙基阳离子物种作为中间体的证据。从头算算结果证实了所提出机制的可行性，并进一步表明，在适度的温度下，在能量上很容易获得氟代碳酸酯类化合物中的1,3-氟转移。修订的C 3 F 8（ΔH ˚F 0 = -1750±12.4千焦耳摩尔-1）和HFP（ΔH ˚F 0 = -1128±千焦耳摩尔-1）已经被算出。据报道，一些简单的金属卤化物具有氟化物亲和力。
• Free radical chemistry. Part 5. [1] A new approach to the synthesis of perfluorinated ethers
  作者：Richard D. Chambers、Brian Grievson、Frederick G. Drakesmith、Richard L. Powell

  DOI：10.1016/s0022-1139(00)82331-3

  日期：1985.9

  Fluorinations of the free-radical adducts of fluorinated alkenes, to ethers, over cobalt trifluoride are described and perfluorinated ethers are obtained at temperatures in excess of 400°C. The effect of structure on the formation of perfluoroethers is outlined.

  描述了在三氟化钴上氟化烯烃的自由基加合物向醚的氟化，并且在超过400°C的温度下获得了全氟化醚。概述了结构对全氟醚形成的影响。
• Plasma levels and metabolism of AcSDKP in patients with chronic renal failure: Relationship with erythropoietin requirements
  作者：Yannick Le Meur、Valérie Lorgeot、Lydie Comte、Jean-Christophe Szelag、Jean-Claude Aldigier、Claude Leroux-Robert、Vincent Praloran

  DOI：10.1053/ajkd.2001.26839

  日期：2001.9

  N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is a physiological inhibitor of hematopoiesis that is maintained at stable levels in normal plasma. Its degradation in vivo and in vitro by angiotensin-converting enzyme (ACE) accounts for the high plasma concentrations of AcSDKP in patients treated with ACE inhibitors. Because ACE inhibitors can induce anemia in some patients, we measured plasma AcSDKP concentrations in 176 patients with chronic renal failure: 120 hemodialysis (HD) and 56 nondialysis (nD) patients, 39 of whom were administered ACE inhibitors. We studied the relationships between AcSDKP levels, hematologic parameters, and recombinant human erythropoietin (rHuEPO) requirements in these patients. AcSDKP levels were significantly greater in HD (10.3 +/- 3.9 pmol/mL) and nD (3.1 +/- 1.8 pmol/mL) patients not administered ACE inhibitors than controls (1.8 +/- 0.2 pmol/mL). In all patients, treatment with ACE inhibitors significantly increased these levels fourfold. HD sessions significantly decreased AcSDKP concentrations by 66% and reduced the predialysis in vitro half-life of AcSDKP (270 +/- 109 minutes) to values (182 +/- 67 minutes) not significantly different from those of controls or nD patients. Most HD patients treated with ACE inhibitors had AcSDKP levels greater than 24 pmol/mL (the greatest concentration found in other nD and HD patients). Only in this group of patients did weekly doses of rHuEPO correlate with AcSDKP levels. Our results show that renal function is essential to maintain stable AcSDKP plasma levels, and at high levels, AcSDKP acts as a uremic toxin causing partial resistance to erythropoietin and inhibiting erythropoiesis. (C) 2001 by the National Kidney Foundation, Inc.
• Synthesis of perfluorobicyclic ethers [1]. The electrochemical fluorination of cycloalkyl-substituted carboxylic acids
  作者：Takashi Abe、Hajime Baba、Eiji Hayashi、Shunji Nagase

  DOI：10.1016/s0022-1139(00)84975-1

  日期：1983.8
• Fluorocarbons by Fluorination of Hydrocarbons with Cobalt Trifluoride
  作者：R. Benner、A. Benning、F. Downing、C. Irwin、K. Johnson、A. Linch、H. Parmelee、W. Wirth

  DOI：10.1021/ie50447a619

  日期：1947.3