4-amino-3-[5-(3-chloro-4-fluoro-benzoylamino)-2-methyl-phenoxymethyl]-thieno[3,2-c]pyridine-7-carboxylic acid ethyl ester 、
C.I.酸性橙108 在
acetonitrile-water 作用下,
以
二甲基亚砜 为溶剂,
反应 2.0h,
以to give 4-amino-3-{5-[3-chloro-4-(2-hydroxy-ethylamino)-benzoylamino)-2-methyl-phenoxymethyl]-thieno[3,2-c]pyridine-7-carboxylic acid (2-hydroxy-ethyl)-amide as white powder的产率得到4-amino-3-{5-[3-chloro-4-(2-hydroxy-ethylamino)-benzoylamino)-2-methyl-phenoxymethyl]-thieno[3,2-c]pyridine-7-carboxylic acid (2-hydroxy-ethyl)-amide