N-benzyl-N-methyl-1-phenylnon-2-yn-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N-methyl-1-phenylnon-2-yn-1-amine
• 化学式: C₂₃H₂₉N
• 分子量: 319.49
• InChiKey: HKTYLJZOYNNGAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-辛炔 、 苯甲醛 、 N-甲基苄胺 在 chitosan(at)CuI 作用下， 以 neat (no solvent) 为溶剂， 反应 0.75h， 以62%的产率得到N-benzyl-N-methyl-1-phenylnon-2-yn-1-amine
  参考文献：
  名称：

  Chitosan-supported copper as an efficient and recyclable heterogeneous catalyst for A3/decarboxylative A3-coupling reaction

  摘要：

  Chitosan-supported copper (chit@copper) based heterogeneous catalysts have been explored for A(3)-coupling and decarboxylative A(3)-coupling. The developed protocol employs low catalyst loading, solventless condition and easy work-up for the synthesis of diversely substituted propargylamines. More importantly, the catalyst could be recovered and reused without any significant loss in the activity. This offer huge advantages as recyclability issues are rarely addressed in decarboxylative A(3)-coupling. Leaching studies were carried out using AAS and ICPMS analysis. It is envisaged that chit@copper catalysts can have potential applications in terms of efficiency and recyclability in the emerging area of decarboxylative C-H bond activation/functionalization strategies. (C) 2018 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2018.03.053