N-benzyl-N-methylpropiolamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N-methylpropiolamide
• 英文别名: N-benzyl-N-methylprop-2-ynamide
• 化学式: C₁₁H₁₁NO
• 分子量: 173.214
• InChiKey: VQOBAVGJYNWTOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-benzyl-N-methylpropiolamide 在 三乙烯二胺 、 N-碘代丁二酰亚胺 、 水 、 palladium diacetate 、 silver nitrate 作用下， 以 丙酮 、 乙腈 为溶剂， 反应 20.0h， 生成 methyl 3-[benzyl(methyl)amino]-3-oxopropanoate
  参考文献：
  名称：

  Palladium-Catalyzed Alcoholysis of 3-Iodopropynamides: Selective Synthesis of Carbamoylacetates

  摘要：

  A novel and selective method for the synthesis of carbamoylacetates via the alcoholysis of 3-iodopropynamides has been developed. 3-Iodopropynamides react with alcohols in the presence of palladium(II) acetate and DABCO to afford the corresponding carbamoylacetates in moderate to good yields.

  DOI：

  10.1055/s-0034-1379104
• 作为产物：
  描述：

  N-甲基苄胺 、 丙炔酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 N-benzyl-N-methylpropiolamide
  参考文献：
  名称：

  Palladium-Catalyzed Alcoholysis of 3-Iodopropynamides: Selective Synthesis of Carbamoylacetates

  摘要：

  A novel and selective method for the synthesis of carbamoylacetates via the alcoholysis of 3-iodopropynamides has been developed. 3-Iodopropynamides react with alcohols in the presence of palladium(II) acetate and DABCO to afford the corresponding carbamoylacetates in moderate to good yields.

  DOI：

  10.1055/s-0034-1379104

文献信息

• Synthesis of 1,1‐Diborylalkenes through a Brønsted Base Catalyzed Reaction between Terminal Alkynes and Bis(pinacolato)diboron
  作者：Akira Morinaga、Kazunori Nagao、Hirohisa Ohmiya、Masaya Sawamura

  DOI：10.1002/anie.201509218

  日期：2015.12.21

  A method for the synthesis of 1,1‐diborylalkenes through a Brønsted base catalyzed reaction between terminal alkynes and bis(pinacolato)diboron has been developed. The procedure allows direct synthesis of functionalized 1,1‐diborylalkenes from various terminal alkynes including propiolates, propiolamides, and 2‐ethynylazoles.

  已经开发了一种通过布朗斯台德碱催化的末端炔烃与双（频哪醇）二硼烷之间的反应来合成1,1-二硼烷基烯烃的方法。该程序可以从各种末端炔烃（包括丙酸酯，丙酰胺和2-乙炔基唑）直接合成官能化的1，1-二硼基烯烃。
• ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1981854B1

  公开（公告）日：2011-06-01
• Palladium-Catalyzed Alcoholysis of 3-Iodopropynamides: Selective Synthesis of Carbamoylacetates
  作者：Can-Cheng Guo、Jian-Sheng Tang

  DOI：10.1055/s-0034-1379104

  日期：——

  A novel and selective method for the synthesis of carbamoylacetates via the alcoholysis of 3-iodopropynamides has been developed. 3-Iodopropynamides react with alcohols in the presence of palladium(II) acetate and DABCO to afford the corresponding carbamoylacetates in moderate to good yields.