3-ethoxybenzyl 4-hydroxybenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-ethoxybenzyl 4-hydroxybenzoate
• 英文别名: (3-Ethoxyphenyl)methyl 4-hydroxybenzoate；(3-ethoxyphenyl)methyl 4-hydroxybenzoate
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.301
• InChiKey: DUSLLCPOIRIVPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-乙氧基-3-甲基苯 、 对羟基苯甲酸 在 sodium bromate 、 sodium hydrogensulfite 作用下， 以 乙酸乙酯 为溶剂， 反应 40.0h， 以84%的产率得到3-ethoxybenzyl 4-hydroxybenzoate
  参考文献：
  名称：

  An expedient esterification of aromatic carboxylic acids using sodium bromate and sodium hydrogen sulfite

  摘要：

  Treatment of aromatic carboxylic acids and substituted toluenes with a mixture of sodium bromate and sodium hydrogen sulfite in a two-phase system gave the corresponding esters in good yield. The intermediate alpha-brominated toluene was formed by the in situ generated hypobromous acid. The alpha-bromotoluene underwent an intermolecular nucleophilic substitution reaction with aromatic carboxylic acids present in the reaction mixture to afford the corresponding esters. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)00812-3

文献信息

• An expedient esterification of aromatic carboxylic acids using sodium bromate and sodium hydrogen sulfite
  作者：Khalid Mohammed Khan、Ghulam Murtaza Maharvi、Safdar Hayat、Zia-Ullah、M. Iqbal Choudhary、Atta-ur-Rahman

  DOI：10.1016/s0040-4020(03)00812-3

  日期：2003.7

  Treatment of aromatic carboxylic acids and substituted toluenes with a mixture of sodium bromate and sodium hydrogen sulfite in a two-phase system gave the corresponding esters in good yield. The intermediate alpha-brominated toluene was formed by the in situ generated hypobromous acid. The alpha-bromotoluene underwent an intermolecular nucleophilic substitution reaction with aromatic carboxylic acids present in the reaction mixture to afford the corresponding esters. (C) 2003 Elsevier Science Ltd. All rights reserved.