2,2'-(4,4'-(propane-2,2-diyl)bis(2,6-dimethyl-4,1-phenylene))-bis(oxy)bis(methylene)dioxirane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-(4,4'-(propane-2,2-diyl)bis(2,6-dimethyl-4,1-phenylene))-bis(oxy)bis(methylene)dioxirane
• 英文别名: 4,4'-(3,3',5,5'-tetramethyl)bisphenol A diglycidyl ether；2-[[4-[2-[3,5-Dimethyl-4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]-2,6-dimethylphenoxy]methyl]oxirane
• 化学式: C₂₅H₃₂O₄
• 分子量: 396.527
• InChiKey: OGZSRGJEJODWKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  43.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2'-(4,4'-(propane-2,2-diyl)bis(2,6-dimethyl-4,1-phenylene))-bis(oxy)bis(methylene)dioxirane 、 甲基丙烯酸 在 2,6-二叔丁基-4-甲基苯酚 、 苄基三甲基氯化铵 作用下， 反应 5.0h， 以96%的产率得到2,2-bis[3,5-dimethyl,4-(2-hydroxy-3-methacryloyloxy propoxy)phenyl]propane
  参考文献：
  名称：

  歯科用硬化性組成物

  摘要：

  【课题】提供一种适度低粘度的牙科用硬化性组合物，即使长期浸泡在水中，硬化体的强度降低也较少。 【解决手段】包含式（1）所示的可聚合单体的牙科用硬化性组合物。 【选择图】无

  公开号：

  JP2018145097A
• 作为产物：
  描述：

  2,2-双(4-羟基-3,5-二甲基苯基)丙烷 、 环氧氯丙烷 在 四丁基溴化铵 、 potassium hydroxide 作用下， 反应 12.0h， 以95%的产率得到2,2'-(4,4'-(propane-2,2-diyl)bis(2,6-dimethyl-4,1-phenylene))-bis(oxy)bis(methylene)dioxirane
  参考文献：
  名称：

  Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as β-Amyloid Peptide Aggregation Inhibitors

  摘要：

  The aggregation of A beta is a crucial step in the etiology of Alzheimer's disease. Our previous work showed that A beta undergoes alpha-helix/beta-sheet intermediate structures during the conformational transition, and an A beta aggregation inhibitor (1) was discovered by targeting the intermediates. Here, structure optimization toward compound 1 was performed and 34 novel derivatives were designed and synthesized. Nine compounds showed more effective inhibitory activity than the hit compound 1 in ThT fluorescence assay. Among them, compound 43 demonstrated more excellent inhibitory potency, which not only can suppress the aggregation of A beta but also can dissolve the preformed fibrils as shown by CD spectroscopy, PICUP and AFM assays. Cellular assay indicated that 43 has no toxicity to neuronal cells, moreover, can effectively inhibit A beta(1-42)-induced neutrotoxicity and increase the cell viability. Together, on the basis of these positive results, these novel chemical structures may provide a promising potential for therapeutic applications in AD and other types of neurodegenerative disorders.

  DOI：

  10.1021/jm1000584

文献信息

• Polyhydroxy polyether, process for its production and its use
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0199564A2

  公开（公告）日：1986-10-29

  A substantially linear polyhydroxy polyether, which (1) is composed substantially of aromatic units and aliphatic units, the proportion of the aromatic units being 50 to 98 mole % based on the total amount of the aromatic units and the aliphatic units, (2) has an intrinsic viscosity, measured at 25°C in o-chlorophenol, of from 0.3 to 2 dl/g, and (3) has a glass transition temperature of from 30 to 120°C. Two processes for preparing the polyhydroxy polyether are proposed. The polyhydroxy polyether is useful in applications which require gas-barrier property.

  一种基本线性的聚羟基聚醚，其(1)主要由芳香族单元和脂肪族单元组成，芳香族单元的比例为 50 至 98 摩尔%（基于芳香族单元和脂肪族单元的总量），(2)在 25°C 邻氯苯酚中测量的固有粘度为 0.3 至 2 分升/克，(3)玻璃化转变温度为 30 至 120°C。提出了制备聚羟基聚醚的两种工艺。这种聚羟基聚醚在需要气体阻隔性能的应用中非常有用。
• RESIN COMPOSITION
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2133380A1

  公开（公告）日：2009-12-16

  A resin composition comprising an epoxy compound denoted by the formula (1): wherein Ar1, Ar2 and Ar3 are the same or different and each denotes any one of divalent groups denoted by the following formulas: wherein R denotes a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and an epoxy compound denoted by the formula (2): wherein R5 denotes a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and Q2 denotes a single bond or a straight-chain alkylene group having 1 to 8 carbon atoms.

  一种树脂组合物，包含由式（1）表示的环氧化合物： 其中 Ar1、Ar2 和 Ar3 相同或不同，且各自表示由下列式子表示的二价基团中的任意一个： 其中 R 表示氢原子或具有 1 至 8 个碳原子的烷基，以及由式 (2) 表示的环氧化合物： 其中 R5 表示氢原子或具有 1 至 8 个碳原子的烷基，Q2 表示单键或具有 1 至 8 个碳原子的直链亚烷基。
• Super-hydrophobic epoxy resin compositions
  申请人：The United States of America, as represented by the Secretary of the Navy

  公开号：US10344160B1

  公开（公告）日：2019-07-09

  An hydrophobic epoxy resin composition including at least one ortho-substituted glycidyl ether, at least one ortho, ortho′-disubstituted glycidyl ether, at least one ortho, meta′-disubstituted glycidyl ether, at least one amine/aniline curing agent, and at least one organic solvent.

  一种疏水性环氧树脂组合物，包括至少一种正代缩水甘油醚、至少一种正、正′-二取代缩水甘油醚、至少一种正、偏′-二取代缩水甘油醚、至少一种胺/苯胺固化剂和至少一种有机溶剂。
• Curing agents for hydrophobic epoxy compositions
  申请人：The United States of America, as represented by the Secretary of the Navy

  公开号：US10711154B1

  公开（公告）日：2020-07-14

  An hydrophobic epoxy resin composition including at least one ortho-substituted glycidyl ether, at least one ortho, ortho′-disubstituted glycidyl ether, at least one ortho, meta′-disubstituted glycidyl ether, at least one amine/aniline curing agent, and at least one organic solvent.

  一种疏水性环氧树脂组合物，包括至少一种正代缩水甘油醚、至少一种正、正′-二取代缩水甘油醚、至少一种正、偏′-二取代缩水甘油醚、至少一种胺/苯胺固化剂和至少一种有机溶剂。
• Sulfur-containing unsaturated carboxylate compound and its use
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1057808B1

  公开（公告）日：2007-03-14