2-(2'-chloro-1',1'-dimethylethyl)ethoxybenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2'-chloro-1',1'-dimethylethyl)ethoxybenzene
• 英文别名: 1-chloro-2-(2-ethoxyphenyl)-2-methylpropane；1-(1-Chloro-2-methylpropan-2-yl)-2-ethoxybenzene
• 化学式: C₁₂H₁₇ClO
• mdl: MFCD00624783
• 分子量: 212.719
• InChiKey: QSTXUWDNHBTZGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯乙醚 、 3-氯-2-甲基丙烯 在 硫酸 作用下， 反应 5.0h， 生成 4-(2'-chloro-1',1'-dimethylethyl)ethoxybenzene 、 2-(2'-chloro-1',1'-dimethylethyl)ethoxybenzene
  参考文献：
  名称：

  摘要：

  An ethophenprox synthesis from, easily available p-nitroneophyl chloride was developed. The reduction of the latter to aniline derivative followed by Sandmayer's and Claisen's reactions furnished p-ethoxyneophyl chloride that by condensation with 3-phenoxybenzyl alcohol in the presence KOH in DMSO yielded ethophenprox.

  DOI：

  10.1023/a:1022562101602

文献信息

• Process for producing 3-phenoxybenzyl 2-(4-alkoxyphenyl)-2-methylpropyl
  申请人：Mitsui Toatsu Chemicals, Inc.

  公开号：US04542243A1

  公开（公告）日：1985-09-17

  The present invention relates to a process for producing 3-phenoxybenzyl 2-(4-alkoxyphenyl)-2-methylpropyl ethers having excellent insecticidal and acaricidal activities which are represented by formula (IV): ##STR1## wherein R is a lower alkyl group and X.sub.1 and X.sub.2 are each a hydrogen or fluorine atom, which comprises reacting a 3-halogeno-4-alkoxyneophyl halide represented by the formula (I): ##STR2## wherein Y.sub.1 and Y.sub.2 are each a hydrogen, chlorine or bromine atom, at least one of them being a chlorine or bromine atom, R has the same meaning as above and X is a halogen atom, with a 3-phenoxybenzyl alcohol represented by the formula (II): ##STR3## wherein X.sub.1 and X.sub.2 have the same meaning as above, in the presence of a base to obtain a 3-phenoxybenzyl 2-(4-alkoxy-3-halogenophenyl)-2-methylpropyl ether represented by the formula (III): ##STR4## wherein Y.sub.1, Y.sub.2, R, X.sub.1 and X.sub.2 have the same meaning as above, and then subjecting the product to a hydrodehalogenation reaction, and relates to a process for producing a 3-halogeno-4-alkoxyneophyl halide represented by formula (I), which comprises reacting a 2-halogeno-1-alkoxybenzene represented by formula (V): ##STR5## wherein Y.sub.1 and Y.sub.2 are each a hydrogen, chlorine or bromine atom, at least one of them being a chlorine or bromine atom, and R represents a lower alkyl group, with a methallyl halide in the presence of an acid catalyst at -20.degree. to 50.degree. C.

  本发明涉及一种生产具有优异杀虫和杀螨活性的3-苯氧基苄基2-(4-烷氧基苯基)-2-甲基丙基醚的方法，其化学式为(IV)：##STR1## 其中，R为低碳基，X1和X2分别为氢或氟原子，其包括通过反应式(I)所表示的3-卤代-4-烷氧基新环烷卤化物：##STR2## 其中，Y1和Y2分别为氢、氯或溴原子，其中至少一个为氯或溴原子，R具有上述相同的含义，X为卤素原子，与式(II)所表示的3-苯氧基苄醇：##STR3## 其中，X1和X2具有上述相同的含义，在碱的存在下，获得式(III)所表示的3-苯氧基苄基2-(4-烷氧基-3-卤苯基)-2-甲基丙基醚：##STR4## 其中，Y1、Y2、R、X1和X2具有上述相同的含义，然后将产物进行脱卤反应，以及一种生产式(I)所表示的3-卤代-4-烷氧基新环烷卤化物的方法，其包括通过反应式(V)所表示的2-卤代-1-烷氧基苯与甲烯丙基卤化物在-20℃至50℃的酸催化剂存在下反应，其中，Y1和Y2分别为氢、氯或溴原子，其中至少一个为氯或溴原子，R表示低碳基。
• Gopalakrishnan, Geetha; Anandhi, S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1995, vol. 34, # 8, p. 722 - 724
  作者：Gopalakrishnan, Geetha、Anandhi, S.

  DOI：——

  日期：——
• US4542243A
  申请人：——

  公开号：US4542243A

  公开（公告）日：1985-09-17
• ——
  作者：R. G. Rakhimov、F. Z. Galin、Yu. V. Tomilov、V. T. Le

  DOI：10.1023/a:1022562101602

  日期：——

  An ethophenprox synthesis from, easily available p-nitroneophyl chloride was developed. The reduction of the latter to aniline derivative followed by Sandmayer's and Claisen's reactions furnished p-ethoxyneophyl chloride that by condensation with 3-phenoxybenzyl alcohol in the presence KOH in DMSO yielded ethophenprox.