六氢-1-(1-氧代十二烷基)-2H-氮杂卓-2-酮 | 5551-77-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 中文名称: 六氢-1-(1-氧代十二烷基)-2H-氮杂卓-2-酮
• 英文名称: 1-dodecanoyl-azepan-2-one
• 英文别名: 1-(1-oxododecyl)azacycloheptan-2-one；1-n-dodecanoylazacycloheptan-2-one；N-Lauroyl-ε-caprolactam；2H-Azepin-2-one, hexahydro-N-lauroyl-；1-dodecanoylazepan-2-one
• CAS: 5551-77-9
• 化学式: C₁₈H₃₃NO₂
• 分子量: 295.466
• InChiKey: JUPACDULOVPQPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  己内酰胺 、 月桂酰氯 以 甲苯 为溶剂， 生成 六氢-1-(1-氧代十二烷基)-2H-氮杂卓-2-酮
  参考文献：
  名称：

  Compositions comprising 1-substituted azacycloalkanes

  摘要：

  本发明提供了一种包含生理活性剂和具有结构式##STR1##的化合物的组合物，其中每个X、Y和Z可以代表氧、硫或两个氢原子，但是，当Z代表两个氢原子时，X和Y都代表氧或硫，当Z代表氧或硫时，至少一个X和Y必须代表氧或硫；m为2-6；R'为H或具有1-4个碳原子的低烷基；n为0-17，R为--CH.sub.3，##STR2##其中R"为H或卤素，其量有效地增强生理活性剂通过动物体的皮肤或其他膜的渗透。

  公开号：

  US05043441A1

文献信息

• Synthesis of Ibuprofen Hybrid Conjugates as Anti-Inflammatory and Analgesic Agents
  申请人：Augusta University Research Institute, Inc.

  公开号：US20210361597A1

  公开（公告）日：2021-11-25

  Disclosed herein as ibuprofen hybrid conjugates and methods of their use to reduce inflammation, pain, and fever. The ibuprofen conjugates have potent anti-inflammatory and analgesic properties with low potential for ulcerogenic activity. An exemplary compound is an ibuprofen-amino acid-4-aminophenol hybrid. Also disclosed are methods of treating or reducing inflammation, pain, and fever in a subject.

  本文披露了一种布洛芬杂交共轭物及其使用方法，用于减轻炎症、疼痛和发热。这些布洛芬共轭物具有强效的抗炎和镇痛特性，且溃疡生成活性低。其中一种示例化合物是布洛芬-氨基酸-4-氨基苯酚杂交物。此外，还披露了在受试者中治疗或减轻炎症、疼痛和发热的方法。
• Compositions comprising 1-substituted azacycloalkanes and their uses
  申请人：Nelson Research & Development Company

  公开号：US04886545A1

  公开（公告）日：1989-12-12

  This invention provides compositions comprising a compound having the structural formula ##STR1## wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents two hydrogen atoms, both X and Y represent oxygen or sulfur and when Z represents oxygen or sulfur at least one of X and Y must represent oxygen or sulfur; m is 2-6; R' is H or a lower alkyl group having 1-4 carbon atoms; n is 0-17 and R is --CH.sub.3, ##STR2## wherein R" is H or halogen. The invention also provides compositions comprising a physiologically-active agent and the hereinabove recited 1-substituted azacycloalkane compound in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal. Other compositions of 1-substituted azacycloalkanes and their uses relate to an improved method of dyeing fibers, improved delivery of plant nutrients, improved plant pest control, improved delivery of plant growth regulations, improved acid-catalyzed conversion of a reactant into a reaction product and an improved insect repellant.

  本发明提供了一种化合物组成物，其具有结构式##STR1##其中每个X、Y和Z可以代表氧、硫或两个氢原子，但是当Z代表两个氢原子时，X和Y都代表氧或硫，当Z代表氧或硫时，至少一个X和Y必须代表氧或硫；m为2-6；R'为H或具有1-4个碳原子的低级烷基；n为0-17，R为--CH.sub.3，##STR2##其中R"为H或卤素。本发明还提供了一种组合物，其中包括生理活性剂和上述1-取代的氮杂环烷化合物，其量足以增强生理活性剂通过动物体的皮肤或其他膜的渗透。1-取代的氮杂环烷化合物的其他组合物及其用途涉及改进的染色纤维方法、改进的植物营养素传递、改进的植物害虫控制、改进的植物生长调节剂传递、改进的酸催化反应物转化为反应产物和改进的昆虫驱避剂。
• Curcumin Conjugates and Methods of Use Thereof
  申请人：Augusta University Research Institute, Inc.

  公开号：US20180110861A1

  公开（公告）日：2018-04-26

  Curcumin-based conjugates and methods of use thereof are provided. Pharmaceutical compositions including an effective amount of one or more curcumin conjugates are also provided. In particular embodiments, the compositions are formulated for oral delivery. The conjugates and pharmaceutical compositions thereof can be administered to a subject in need thereof to treat a host of diseases and disorders including but not limited to, cancer, inflammation, and microbial growth.

  提供基于姜黄素的共轭物及其使用方法。还提供包括一种或多种姜黄素共轭物的有效量的制药组合物。在特定实施例中，这些组合物是为口服递送而制剂的。这些共轭物和其制药组合物可以被用于治疗患有多种疾病和障碍的患者，包括但不限于癌症、炎症和微生物生长。
• Methods for administration using 1-substituted azacycloalkanes
  申请人：Whitby Research, Inc.

  公开号：US05034386A1

  公开（公告）日：1991-07-23

  This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents two hydrogen atoms, both X and Y represent oxygen or sulfur and when Z represents oxygen or sulfur at least one of X and Y must represent oxygen or sulfur; m is 2-6; R' is H or a lower alkyl group having 1-4 carbon atoms; n is 0-17 and R is --CH.sub.3, ##STR2## wherein R" is H or halogen in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal.

  本发明提供了一种由具有生理活性的药剂和具有结构式##STR1##的化合物组成的组合物，其中每个X、Y和Z可以表示氧、硫或两个氢原子，但是当Z表示两个氢原子时，X和Y都表示氧或硫，当Z表示氧或硫时，至少一个X和Y必须表示氧或硫；m为2-6；R'为H或具有1-4个碳原子的低烷基基团；n为0-17，R为--CH.sub.3，##STR2##其中R"为H或卤素，其量有效增强生理活性药剂穿透动物皮肤或其他膜的能力。
• [EN] GLYCOSYLATED HISTONE DEACETYLASE INHIBITORS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] INHIBITEURS GLYCOSYLÉS D'HISTONE DÉSACÉTYLASE ET LEURS MÉTHODES DE FABRICATION ET D'UTILISATION
  申请人：GEORGIA TECH RES INST

  公开号：WO2022146994A1

  公开（公告）日：2022-07-07

  Provided herein are glycosylated compounds as histone deacetylase (HDACi) inhibitors or a diastereomer, solvate, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions and medicaments that include the compounds described herein as well as methods of treating inflammatory disease and cancer.

  本文提供了作为组蛋白去乙酰化酶抑制剂（HDACi）或其对映体、溶剂化物或药学上可接受的盐的糖基化化合物。还提供了包括上述化合物的药物组合物和药物以及治疗炎症性疾病和癌症的方法。