(E)-1-(2,4-dichlorobenzylidene)-2-(2,4-dinitrophenyl)hydrazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-(2,4-dichlorobenzylidene)-2-(2,4-dinitrophenyl)hydrazine
• 英文别名: 2,4-dichloro-benzaldehyde-(2,4-dinitro-phenylhydrazone)；2,4-Dichlor-benzaldehyd-(2,4-dinitro-phenylhydrazon)；N-[(E)-(2,4-dichlorophenyl)methylideneamino]-2,4-dinitroaniline
• 化学式: C₁₃H₈Cl₂N₄O₄
• 分子量: 355.137
• InChiKey: QRDBJQZESKHFMQ-FRKPEAEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,4-二氯苯甲醛 、 2,4-二硝基苯肼 在 硫酸 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以89%的产率得到(E)-1-(2,4-dichlorobenzylidene)-2-(2,4-dinitrophenyl)hydrazine
  参考文献：
  名称：

  SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE

  摘要：

  A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50-99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation.

  DOI：

  10.4067/s0717-97072016000300015

文献信息

• SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE
  作者：SERGIO ORTIZ、RONALD NELSON、VÍCTOR KESTERNICH、MARCIA PÉREZ-FEHRMANN、PHILIPPE CHRISTEN、LAURENCE MARCOURT

  DOI：10.4067/s0717-97072016000300015

  日期：——

  A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50-99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation.