(E)-styryl dipentylphosphine oxide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-styryl dipentylphosphine oxide
• 英文别名: [(E)-2-dipentylphosphorylethenyl]benzene
• 化学式: C₁₈H₂₉OP
• 分子量: 292.401
• InChiKey: OTEPCODFKCBSPN-SAPNQHFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  dipentylphosphine oxide 、 苯丙炔酸 在 copper(l) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以84%的产率得到(E)-styryl dipentylphosphine oxide
  参考文献：
  名称：

  Copper-Catalyzed Decarboxylative C–P Cross-Coupling of Alkynyl Acids with H-Phosphine Oxides: A Facile and Selective Synthesis of (E)-1-Alkenylphosphine Oxides

  摘要：

  A novel and efficient copper-catalyzed decarboxylative cross-coupling of alkynyl acids for the stereoselective synthesis of E-alkenylphosphine oxides has been developed. In the presence of 10 mol % of CuCl without added ligand, base, and additive, various alkynyl acids reacted with H-phosphine oxides to afford E-alkenylphosphine oxides with operational simplicity, broad substrate scope, and the stereoselectivity for E-isomers.

  DOI：

  10.1021/ol502009b

文献信息

• Copper-Catalyzed Decarboxylative C–P Cross-Coupling of Alkynyl Acids with <i>H</i>-Phosphine Oxides: A Facile and Selective Synthesis of (<i>E</i>)-1-Alkenylphosphine Oxides
  作者：Gaobo Hu、Yuxing Gao、Yufen Zhao

  DOI：10.1021/ol502009b

  日期：2014.9.5

  A novel and efficient copper-catalyzed decarboxylative cross-coupling of alkynyl acids for the stereoselective synthesis of E-alkenylphosphine oxides has been developed. In the presence of 10 mol % of CuCl without added ligand, base, and additive, various alkynyl acids reacted with H-phosphine oxides to afford E-alkenylphosphine oxides with operational simplicity, broad substrate scope, and the stereoselectivity for E-isomers.