2-amino-3-methyl-1-phenylbutane hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-3-methyl-1-phenylbutane hydrochloride
• 英文别名: (3-methyl-1-phenylbutan-2-yl)azanium;chloride
• 化学式: C₁₁H₁₇N*ClH
• 分子量: 199.724
• InChiKey: ZOYFCWMWEVFHMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.63
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-amino-3-methyl-1-phenylbutane hydrochloride 生成 1-phenyl-3-propan-2-ylisoquinoline
  参考文献：
  名称：

  Ardabilchi, Nasser; Fitton, Alan O.; Hadi, A. Hamid b. A., Journal of Chemical Research, Miniprint, 1982, # 6, p. 1710 - 1725

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基-1-苯基-2-丁酮 在 palladium on activated charcoal 盐酸 、 氢气 、 羟胺 作用下， 生成 2-amino-3-methyl-1-phenylbutane hydrochloride
  参考文献：
  名称：

  Ardabilchi, Nasser; Fitton, Alan O.; Hadi, A. Hamid b. A., Journal of Chemical Research, Miniprint, 1982, # 6, p. 1710 - 1725

  摘要：

  DOI：

文献信息

• Irreversible HIV protease inhibitors, intermediates, compositions and
  申请人：LG Chemical Limited

  公开号：US05696134A1

  公开（公告）日：1997-12-09

  Novel cis-epoxide compounds of formula (I) are useful for treating or preventing diseases caused by HIV infection: ##STR1## wherein A, B, R.sub.1 to R.sub.4 and n have the same meanings as defined in the specification. The novel HIV protease inhibitor of the formula (I) has a specific structure to form a stable bonding with the enzyme active site, which entails a highly enhanced irreversible inhibition against HIV protease.

  化合物的新颖顺式环氧化物化合物（I）可用于治疗或预防由HIV感染引起的疾病：其中A、B、R.sub.1至R.sub.4和n的含义与规范中定义的含义相同。公式（I）的新型HIV蛋白酶抑制剂具有特定结构，可与酶活性位点形成稳定结合，从而对HIV蛋白酶产生高度增强的不可逆抑制作用。
• Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof
  申请人：LG Chemical Limited

  公开号：EP0687675A3

  公开（公告）日：1996-03-06

  Novel cis-epoxide compounds of formula (I) are useful for treating or preventing diseases caused by HIV infection: wherein A, B, R1 to R4 and n have the same meanings as defined in the specification.The novel HIV protease inhibitor of the formula (I) has a specific structure to form a stable bonding with the enzyme active site, which entails a highly enhanced irreversible inhibition against HIV protease.

  新的cis-环氧化合物的化学式（I）对治疗或预防由HIV感染引起的疾病有用：其中A、B、R1至R4和n的含义与规范中定义的相同。化学式（I）的新型HIV蛋白酶抑制剂具有特定结构，能与酶活性位点形成稳定的结合，从而实现对HIV蛋白酶高度增强的不可逆抑制。
• Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof
  申请人：LG Chemical Limited

  公开号：EP0812839A1

  公开（公告）日：1997-12-17

  The present invention relates to novel compounds of formula (I) which has inhibitory activities against human immunodeficiency virus ("HIV") protease, a process for the preparation thereof, and compositions for prevention or treatment of AIDS by HIV infection comprising the above compounds as active ingredients. wherein: R1 is an aromatic group, a nitrogen-containing aromatic group, C1-4 alkyl group optionally substituted with an aromatic group or a nitrogen-containing aromatic group, C1-4 alkoxy group optionally substituted with an aromatic group or a nitrogen-containing aromatic group; R2 is an amino acid residue or a C1-8 alkyl group substituted with a C1-4 alkylsulfonyl group; R3 is a C1-4 alkyl group optionally substituted with an aromatic group; R4 is hydrogen or a C1-2 alkyl group; R5 is a C1-10 alkyl group optionally substituted with an aromatic group; and n is 1 or 2.

  本发明涉及具有对人类免疫缺陷病毒（“HIV”）蛋白酶具有抑制活性的化合物的新型化合物（I）的公式，以及其制备方法，以及包括上述化合物作为活性成分的用于预防或治疗HIV感染引起的艾滋病的组合物。其中：R1是芳香基，含氮芳香基，C1-4烷基，可选地取代为芳香基或含氮芳香基的C1-4烷基，或可选地取代为芳香基或含氮芳香基的C1-4烷氧基；R2是氨基酸残基或取代为C1-4烷基磺酰基的C1-8烷基；R3是可选地取代为芳香基的C1-4烷基；R4是氢或C1-2烷基；R5是可选地取代为芳香基的C1-10烷基；n为1或2。
• Irreversible HIV protease inhibitors, compositions containing same and
  申请人：LG Chemical Limited

  公开号：US05670517A1

  公开（公告）日：1997-09-23

  The present invention relates to novel compounds of formula (I) which has inhibitory activities against human immunodeficiency virus ("HIV") protease, a process for the preparation thereof, and compositions for prevention or treatment of AIDS by HIV infection comprising the above compounds as active ingredients. ##STR1## wherein: R.sup.1 is an aromatic group, a nitrogen-containing aromatic group, C.sub.1-4 alkyl group optionally substituted with an aromatic group or a nitrogen-containing aromatic group, C.sub.1-4 alkoxy group optionally substituted with an aromatic group or a nitrogen-containing aromatic group; R.sup.2 is an amino acid residue or a C.sub.1-8 alkyl group substituted with a C.sub.1-4 alkylsulfonyl group; R.sup.3 is a C.sub.1-4 alkyl group optionally substituted with an aromatic group; R.sup.4 is hydrogen or a C.sub.1-2 alkyl group; R.sup.5 is a C.sub.1-10 alkyl group optionally substituted with an aromatic group; and n is 1 or 2.

  本发明涉及一种具有对人类免疫缺陷病毒（“HIV”）蛋白酶抑制活性的化合物（I）的新型化合物，以及其制备方法，以及包含上述化合物作为活性成分的用于预防或治疗艾滋病的组合物。其中：R.sup.1是芳香族基，含氮芳香族基，C.sub.1-4烷基（可选地取代芳香族基或含氮芳香族基），或C.sub.1-4烷氧基（可选地取代芳香族基或含氮芳香族基）；R.sup.2是氨基酸残基或C.sub.1-8烷基（取代有C.sub.1-4烷基磺酰基）；R.sup.3是C.sub.1-4烷基（可选地取代芳香族基）；R.sup.4是氢或C.sub.1-2烷基；R.sup.5是C.sub.1-10烷基（可选地取代芳香族基）；n为1或2。
• Cis-epoxide derivatives useful as irreversible HIV protease inhibitors and process and intermediates for their preparation
  申请人：LUCKY LTD.

  公开号：EP0601486B1

  公开（公告）日：1997-10-29