phenyl 3-(1-acetyl-2-oxocyclopentyl)propanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: phenyl 3-(1-acetyl-2-oxocyclopentyl)propanoate
• 英文别名: Phenyl 3-(1-acetyl-2-oxocyclopentyl)propanoate
• 化学式: C₁₆H₁₈O₄
• 分子量: 274.317
• InChiKey: DVNOOYAEDKWGTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-乙酰基环戊酮 、 丙烯酸苯酯 在 1,5,7-三氮杂双环[4.4.0]癸-5-烯 作用下， 以 甲苯 为溶剂， 反应 0.5h， 以97%的产率得到phenyl 3-(1-acetyl-2-oxocyclopentyl)propanoate
  参考文献：
  名称：

  1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) catalyzed Michael reactions

  摘要：

  1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD), a bicyclic guanidine base, has been found to be an excellent catalyst for Michael and Michael-type reactions. A wide variety of Michael donors and acceptors can participate in these reactions using 10-20 mol% of TDB. These reactions are mild, fast, easy to perform, produce excellent yields and can occur in several solvents without the need for strictly anhydrous conditions. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.08.010

文献信息

• 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) catalyzed Michael reactions
  作者：Weiping Ye、Junye Xu、Chin-Tong Tan、Choon-Hong Tan

  DOI：10.1016/j.tetlet.2005.08.010

  日期：2005.10

  1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD), a bicyclic guanidine base, has been found to be an excellent catalyst for Michael and Michael-type reactions. A wide variety of Michael donors and acceptors can participate in these reactions using 10-20 mol% of TDB. These reactions are mild, fast, easy to perform, produce excellent yields and can occur in several solvents without the need for strictly anhydrous conditions. (c) 2005 Elsevier Ltd. All rights reserved.