利多卡因N-乙基溴 | 21306-56-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 利多卡因N-乙基溴
• 中文别名: 2,4-二氨基苯乙醚；QX-314
• 英文名称: QX 314
• 英文别名: N-ethyllidocaine；2-[(2,6-dimethylphenyl)amino]-N,N,N-triethyl-2-oxoethanaminium；[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium
• CAS: 21306-56-9
• 化学式: C₁₆H₂₇N₂O
• 分子量: 263.403
• InChiKey: PYEBKOFMWAMBFV-UHFFFAOYSA-O

物化性质

• 熔点：
  220 - 222°C
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• 海关编码：
  2924299090
• WGK Germany：
  3

文献信息

• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Compositions for treating pain and pruritus
  申请人：President and Fellows of Harvard College

  公开号：EP2425858A2

  公开（公告）日：2012-03-07

  The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.

  本发明的特征是一种抑制细胞中一个或多个电压门控离子通道的方法，其方法是将细胞与(i) 第一种化合物接触，该化合物可激活存在于痛觉感受器和/或瘙痒感受器上的通道形成受体；和(ii)第二种化合物，它在作用于通道的内面时抑制一个或多个电压门控离子通道，但在作用于通道的外面时并不实质上抑制所述通道，其中第二种化合物在受体被激活时能够通过通道形成受体进入痛觉感受器或刺痛感受器。本发明还有一种季胺衍生物或其他永久或瞬时带电的化合物衍生物，当作用于一个或多个电压门控离子通道的内部面时，可抑制该通道，但作用于通道的外部面时，不会对上述通道产生实质性的抑制作用。
• Methods, compositions, and kits for treating pain and pruritis
  申请人：President and Fellows of Harvard College

  公开号：EP2446903A2

  公开（公告）日：2012-05-02

  The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.

  本发明的特征是一种抑制细胞中一个或多个电压门控离子通道的方法，其方法是将细胞与(i) 第一种化合物接触，该化合物可激活存在于痛觉感受器和/或瘙痒感受器上的通道形成受体；和(ii)第二种化合物，它在作用于通道的内面时抑制一个或多个电压门控离子通道，但在作用于通道的外面时并不实质上抑制所述通道，其中第二种化合物在受体被激活时能够通过通道形成受体进入痛觉感受器或刺痛感受器。本发明还有一种季胺衍生物或其他永久或瞬时带电的化合物衍生物，当作用于一个或多个电压门控离子通道的内部面时，可抑制该通道，但作用于通道的外部面时，不会对上述通道产生实质性的抑制作用。
• Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
  申请人：Children's Medical Center Corporation

  公开号：US10729664B2

  公开（公告）日：2020-08-04

  The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.

  本发明提供了用于治疗神经源性炎症的化合物、组合物、方法和试剂盒。
• Treating and preventing diseases by modulating cell mechanics
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US10787410B2

  公开（公告）日：2020-09-29

  Described are methods of treating or preventing a disease in a subject treatable by modulating cell mechanics. The method includes administering to a subject having or at risk for such a disease a pharmaceutical composition comprising an agent selected from the group comprising a salt, solvate, or stereoisomer of compound (VIII) or its derivatives or a mixture of their constituents, where the compound has the formula:

  描述了通过调节细胞力学来治疗或预防受试者疾病的方法。该方法包括向患有这种疾病或有这种疾病风险的受试者施用药物组合物，该组合物包含选自化合物(VIII)或其衍生物的盐、溶解物或立体异构体或其成分混合物的组的制剂，其中化合物具有式：