(2S)-3-(4-ethoxyphenyl)-2-(methylamino)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-3-(4-ethoxyphenyl)-2-(methylamino)propanoic acid
• 化学式: C₁₂H₁₇NO₃
• 分子量: 223.27
• InChiKey: XKNKVGNAUYLLLD-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COMPLEX HAVING ANTI-HUMAN MUC1 ANTIBODY FAB FRAGMENT, PEPTIDE LINKER AND/OR LIGAND
  申请人：Astellas Pharma Inc.

  公开号：US20210340276A1

  公开（公告）日：2021-11-04

  Provided are a conjugate comprising an anti-human MUC1 antibody Fab fragment and a peptide linker and/or a ligand, a composition for diagnosis and/or a pharmaceutical composition comprising the conjugate, a method for diagnosing and/or treating a cancer using the conjugate, and the like. In the conjugate used, the anti-human MUC1 antibody Fab fragment is bound to the ligand via the peptide linker or the like.
• CONJUGATE COMPRISING LIGAND, SPACER, PEPTIDE LINKER, AND BIOMOLECULE
  申请人：ASTELLAS PHARMA INC.

  公开号：US20220105194A1

  公开（公告）日：2022-04-07

  Provided is a conjugate comprising a ligand, a spacer, and a peptide linker useful for an in-vivo diagnostic drug and internal radiation therapy, using an anti-human MUC1 antibody Fab fragment whose binding activity is not attenuated even by labeling with a metal, a fluorescent dye, or the like. A conjugate comprising 3arm DOTA, a specific spacer, a specific peptide linker, and a biomolecule including an anti-human MUC1 antibody Fab fragment, wherein the binding activity thereof is not attenuated even by labeling with a metal, a fluorescent dye, or the like, can be used as a diagnostic composition and/or a pharmaceutical composition.
• [EN] SYNTHESIS AND COMPOSITION OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR THE TARGETED IMAGING OF TUMORS<br/>[FR] SYNTHÈSE ET COMPOSITION DE GROUPES DE LIAISON D'ACIDES AMINÉS CONJUGUÉS À DES COMPOSÉS UTILISÉS POUR L'IMAGERIE CIBLÉE DE TUMEURS
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：WO2014149069A1

  公开（公告）日：2014-09-25

  The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
• [EN] PATIENT SELECTION METHOD FOR INFLAMMATION<br/>[FR] MÉTHODE DE SÉLECTION DE PATIENT POUR LE TRAITEMENT DE L'INFLAMMATION
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：WO2015077303A1

  公开（公告）日：2015-05-28

  The invention relates to methods and compositions for the selection of patients for therapy with an anti-inflammatory drug. More particularly, the invention relates to compositions comprising folate-imaging agent conjugates for the selection of patients for therapy with an anti-inflammatory drug, and methods and uses therefor.