5.7-Dioxo-octansaeure-ethylester

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5.7-Dioxo-octansaeure-ethylester
• 英文别名: Ethyl 5,7-dioxooctanoate；ethyl 5,7-dioxooctanoate
• 化学式: C₁₀H₁₆O₄
• 分子量: 200.235
• InChiKey: MIRQDCVZNWQNGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  戊二酸单乙酯酰氯 在 水 作用下， 生成 5.7-Dioxo-octansaeure-ethylester
  参考文献：
  名称：

  Gelin,R.; Gelin,S., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1964, vol. 258, p. 4783 - 4784

  摘要：

  DOI：

文献信息

• New insights into the reduction of β,δ-diketo-sulfoxides
  作者：Gilles Hanquet、Xavier J. Salom-Roig、Laurence Gressot-Kempf、Steve Lanners、Guy Solladié

  DOI：10.1016/s0957-4166(03)00125-3

  日期：2003.5

  New developments in the reduction of beta,delta-diketo-sulfoxides, a reaction that affords important key intermediates for total synthesis, are described. We showed without ambiguity using NMR experiments, that the beta-carbonyl group is totally enolised. This result is inconsistent with the previous hypothesis, which supposed the other tautomer (enolisation at the delta-position) as the major one. We propose a rationale to explain the side reactions occurring during the reduction of unprotected beta,delta-diketo-sulfoxides and showed that judicious protection of the delta-carbonyl group gave all diastereoisomers of beta-hydroxy-delta-ketosulfoxides. (C) 2003 Elsevier Science Ltd. All rights reserved.
• Multifunctional Degradable Nanoparticles with Control over Size and Functionalities
  申请人：Vanderbilt University

  公开号：US20160237208A1

  公开（公告）日：2016-08-18

  In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymers and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US9856348B2
  申请人：——

  公开号：US9856348B2

  公开（公告）日：2018-01-02
• Gelin,R.; Gelin,S., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1964, vol. 258, p. 4783 - 4784
  作者：Gelin,R.、Gelin,S.

  DOI：——

  日期：——