功能化聚丙烯酰胺 | 151954-97-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 功能化聚丙烯酰胺
• 中文别名: 聚(N-异丙基丙烯酰胺-co－甲基丙烯酸)；功能化聚(N-异丙基丙烯酰胺)
• 英文名称: 2-methylprop-2-enoic acid;N-propan-2-ylprop-2-enamide
• CAS: 151954-97-1
• 化学式: C10H17NO3
• 分子量: 199.25
• InChiKey: BGJOTKHBFYMJST-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.34
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Novel colloid synthetic vectors for gene therapy
  申请人：——

  公开号：US20030166601A1

  公开（公告）日：2003-09-04

  Non-naturally occurring vector for gene therapy are provided, comprised of chemically defined reagents, where the vector is self-assembling and where the vector comprises (1) a core complex comprising a nucleic acid and (2) at least one complex forming reagent, where the vector has fusogenic activity. The vector optionally may contain reagents permitting fusion with cell membranes and nuclear uptake. The vector also may contain an outer shell moiety that is anchored to the core complex, whereby the outer shell stabilizes the complex, protects it from unwanted interactions and enhances delivery of the nucleic acid into a target tissue or cell. The outer shell optionally may be sheddable, that is, it may be designed such that it dissociates from the vector upon entry into the target cell or tissue.

  提供了一种非自然发生的基因治疗载体，由化学定义的试剂组成，其中载体是自组装的，包括（1）核酸的核心复合物和（2）至少一个复合物形成试剂，其中载体具有融合活性。该载体可选地包含允许与细胞膜融合和核摄取的试剂。该载体还可以包含一个外壳基团，该基团固定在核心复合物上，从而稳定外壳，保护它免受不必要的相互作用，并增强核酸传递到目标组织或细胞的能力。外壳可选地可脱落，即它可以被设计成在进入目标细胞或组织时与载体分离。
• Thermosensitive polymer carriers having a modifiable physical structure for biochemical analysis, diagnosis and therapy
  申请人：Muller-Schulte P Detlef

  公开号：US20050175702A1

  公开（公告）日：2005-08-11

  The invention relates to thermosensitive polymers which contain magnetic and/or metallic colloids and whose physical structure can be altered through magnetic induction or through the supply of energy. The invention also relates to processes for the production of such thermosensitive polymers, and the use of such polymers for diagnostic and therapeutic purposes.

  本发明涉及含有磁性和/或金属胶体的热敏性聚合物，其物理结构可通过磁感应或提供能量而改变。本发明还涉及生产这种热敏聚合物的工艺，以及将这种聚合物用于诊断和治疗目的。
• Hpma-polyamine conjugates and uses therefore
  申请人：Ghandehari Hamidreza

  公开号：US20060014695A1

  公开（公告）日：2006-01-19

  The inventions provide compositions and methods for nucleic acid delivery comprising IIPMA conjugated to a polyamine. These compositions have the benefit of the steric hindrance of HPMA and the nucleic acid binding capability of a polyamine. Useful polyamines for this purpose include spermine, spermidine and their analogues, and DFMO. These polyamines have the ability not only to bind nucleic acids, but also have anti-cancer effects themselves. The compounds provided can also include ligand binding domains, such as vascular endothelial growth factors, somatostatin and somatostatin analogs, transferring, melanotropin, ApoE and ApoE peptides, von Willebrand's factor and von Willebrand's factor peptides, adenoviral fiber protein and adenoviral fiber protein peptides, PD 1 and PD 1 peptides, EGF and EGF peptides, RGD peptides, CCK peptides, antibody and antibody fragments, folate, pyridoxyl and sialyl-LewisX and chemical analogs. Methods for using these compositions to achieve a therapeutic effect, including for vaccination, are also provided.

  本发明提供了用于递送核酸的组合物和方法，其中包括与多胺共轭的 IIPMA。这些组合物具有 HPMA 的立体阻碍和多胺的核酸结合能力。为此，有用的多胺包括精胺、亚精胺及其类似物和 DFMO。这些多胺不仅具有结合核酸的能力，而且本身还具有抗癌作用。所提供的化合物还可以包括配体结合域，如血管内皮生长因子、体生长抑素和体生长抑素类似物、转移素、黑色素生成素、载脂蛋白E和载脂蛋白E肽、von Willebrand因子和von Willebrand因子肽、腺病毒纤维蛋白和腺病毒纤维蛋白肽、PD 1 和 PD 1 肽、EGF 和 EGF 肽、RGD 肽、CCK 肽、抗体和抗体片段、叶酸、吡哆醇和 sialyl-LewisX 以及化学类似物。还提供了使用这些组合物达到治疗效果的方法，包括用于疫苗接种的方法。
• Polymers for delivering peptides and small molecules in vivo
  申请人：Scaria V. Puthupparampil

  公开号：US20060051315A1

  公开（公告）日：2006-03-09

  Certain hydrophilic polymers, such as a polyoxazoline, when conjugated to a polypeptide or small molecule agent, can enhance the bioavailability of the agent when administered in vivo. Accordingly, hydrophilic polymers of the invention can be used as a delivery vehicle to treat any number of disorders and/or confer a myriad of therapeutic benefits to a subject.

  某些亲水性聚合物，如聚噁唑啉，在与多肽或小分子制剂共轭时，可提高制剂在体内给药时的生物利用度。因此，本发明的亲水性聚合物可用作给药载体，用于治疗各种疾病和/或给受试者带来各种治疗益处。
• POLYMERS FOR DELIVERING PEPTIDES AND SMALL MOLECULES I IN VIVO /I
  申请人：Intradigm Corporation

  公开号：EP1480657A1

  公开（公告）日：2004-12-01