(3S,4R)-2,4-Dimethyl-3-(N-benzoylamino)hept-6-en-4-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S,4R)-2,4-Dimethyl-3-(N-benzoylamino)hept-6-en-4-ol
• 英文别名: N-[(3S,4R)-4-hydroxy-2,4-dimethylhept-6-en-3-yl]benzamide
• 化学式: C₁₆H₂₃NO₂
• 分子量: 261.364
• InChiKey: ZTDITYUKPMXOPG-GOEBONIOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-benzoyl-L-valine 在 sodium hydroxide 、 sodium perborate 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 5.0h， 生成 (3S,4R)-2,4-Dimethyl-3-(N-benzoylamino)hept-6-en-4-ol
  参考文献：
  名称：

  Allylboration of .alpha.-Amino Ketones

  摘要：

  A series of unsaturated alpha-amino alcohols were prepared via the allylboration of the corresponding N-protected alpha-amino ketones. The reactions are stereoselective, producing the syn isomers. The diastereoselectivity is not dramatically effected by the electronic nature of the N-protecting group or the reaction temperature but is dependent on the steric requirements of the N-protecting group and the solvent system.

  DOI：

  10.1021/jo00120a029

文献信息

• Allylboration of .alpha.-Amino Ketones
  作者：R. David Pace、George W. Kabalka

  DOI：10.1021/jo00120a029

  日期：1995.7

  A series of unsaturated alpha-amino alcohols were prepared via the allylboration of the corresponding N-protected alpha-amino ketones. The reactions are stereoselective, producing the syn isomers. The diastereoselectivity is not dramatically effected by the electronic nature of the N-protecting group or the reaction temperature but is dependent on the steric requirements of the N-protecting group and the solvent system.