methyl decylcarbamate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl decylcarbamate
• 英文别名: methyl N-decylcarbamate
• 化学式: C₁₂H₂₅NO₂
• 分子量: 215.336
• InChiKey: ROWGSLJWGZHZKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl decylcarbamate 以90%的产率得到
  参考文献：
  名称：

  Rane Dhanajay S., Sharma Man M., J. Chem. Technol. and Biotechnol, 59 (1994) N 3, S 271-277

  摘要：

  DOI：
• 作为产物：
  描述：

  十一碳酰胺 以94%的产率得到
  参考文献：
  名称：

  Rane Dhanajay S., Sharma Man M., J. Chem. Technol. and Biotechnol, 59 (1994) N 3, S 271-277

  摘要：

  DOI：

文献信息

• Dimethyl Carbonate as an Ambident Electrophile
  作者：Pietro Tundo、Laura Rossi、Alessandro Loris

  DOI：10.1021/jo048532b

  日期：2005.3.1

  character (aliphatic and aromatic amines, alcohoxydes, phenoxides, thiolates) are compared with regard to nucleophilic substitutions on dimethyl carbonate (DMC), using different reaction conditions. Results are well in agreement with the Hard−Soft Acid−Base (HSAB) theory. Accordingly, the high selectivity of monomethylation of CH2 acidic compounds and primary aromatic amines with DMC can be explained

  使用不同的反应条件，对碳酸二甲酯（DMC）上的亲核取代进行了比较，对具有不同软/硬特性的各种阴离子（脂肪族和芳香族胺，烷氧基，酚盐，硫醇盐）的特征进行了比较。结果与硬质酸碱（HSAB）理论完全吻合。因此，CH 2的单甲基化的高选择性DMC中的酸性化合物和伯芳族胺可以通过两个不同的后续反应来解释，这是由于DMC具有双重亲电特性。第一步由硬-硬反应组成，选择性地产生软阴离子，在第二相中，通过软-软亲核取代（使用DMC，在完全转化时收率> 99％）选择性转化为最终的单甲基化产物作为溶剂）。
• Preparation of a novel bromine complex and its application in organic synthesis
  作者：Yuya Nishio、Kotaro Yubata、Yutaro Wakai、Kotaro Notsu、Katsumi Yamamoto、Hideki Fujiwara、Hiroshi Matsubara

  DOI：10.1016/j.tet.2019.01.055

  日期：2019.3

  Although molecular bromine (Br2) is a useful brominating reagent, it is not easy to handle. Herein, we describe the preparation of a novel air-stable bromine complex prepared from 1,3-dimethyl-2-imidazolidinone (DMI) and Br2, which was identified to be (DMI)2HBr3 by spectral and X-ray techniques. This complex was then used to brominate olefins, carbonyl compounds, and aromatics, as well as in the Hofmann

  尽管分子溴（Br 2）是有用的溴化剂，但操作起来并不容易。本文中，我们描述了由1,3-二甲基-2-咪唑啉酮（DMI）和Br 2（通过光谱和X射线技术鉴定为（DMI）2 HBr 3）制备的新型空气稳定溴配合物的制备。然后将该络合物用于溴化烯烃，羰基化合物和芳族化合物，以及用于霍夫曼重排。使用该配合物的反应产物的收率几乎与使用其他溴替代物的反应产物的收率几乎相同或更高。
• The synthesis of alkyl carbamates from primary aliphatic amines and dialkyl carbonates in supercritical carbon dioxide
  作者：Maurizio Selva、Pietro Tundo、Alvise Perosa

  DOI：10.1016/s0040-4039(01)02390-5

  日期：2002.2

  130°C and in the presence of compressed CO2, primary aliphatic amines [RNH2, R=C10H21, C8H17, cHex, 1-(C10H7)CH2] react with organic carbonates (R′OCO2R; R′=Me, Et) to give alkyl carbamates (RNHCO2R′, 1). Although CO2 promotes the reaction also at a low pressure, good yields (∼80%) of 1 are achievable only with supercritical carbon dioxide (scCO2) at 90 bar, which inhibits the formation of N-methylated

  在130°C且存在压缩CO 2的情况下，伯脂肪族胺[RNH 2，R = C 10 H 21，C 8 H 17，cHex，1-（C 10 H 7）CH 2 ]与有机碳酸酯（ R′OCO 2 R； R′＝ Me，Et）得到氨基甲酸烷基酯（RNHCO 2 R′，1）。尽管CO 2在低压下也能促进反应，但仅在90 bar的超临界二氧化碳（scCO 2）的情况下，才能达到1的良好收率（〜80％），这会抑制N-甲基化副产物的形成。
• METHOD FOR TREATMENT OF ISOCYANATE RESIDUE, AND METHOD FOR TREATMENT OF CARBONATE
  申请人：Shimokawatoko Yoshiki

  公开号：US20120271067A1

  公开（公告）日：2012-10-25

  A method for treating an isocyanate residue, which comprises carrying out a thermal decomposition reaction of a carbamate that is produced by the reaction among an amine, urea and/or an N-unsubstituted carbamic acid ester and an alcohol to produce a decomposition solution, separating an isocyanate and the alcohol from the decomposition solution to produce the isocyanate residue, and bringing the isocyanate residue into contact with high-pressure/high-temperature water to decompose the isocyanate residue into an amine; and a method for treating a carbonate, which comprises bringing the carbonate into contact with high-pressure/high-temperature water to decompose the carbonate into an alcohol.

  一种处理异氰酸酯残留物的方法，包括进行热分解反应，将胺、尿素和/或一种未取代的N-氨基甲酸酯和醇反应生成的氨基甲酸酯分解为分解液，从分解液中分离出异氰酸酯和醇，产生异氰酸酯残留物，并将异氰酸酯残留物与高压/高温水接触以将异氰酸酯残留物分解为胺；以及一种处理碳酸盐的方法，包括将碳酸盐与高压/高温水接触以将碳酸盐分解为醇。
• Carbamate synthesis from amines and dialkyl carbonate over inexpensive and clean acidic catalyst—Sulfamic acid
  作者：Bo Wang、Jing He、Run Cang Sun

  DOI：10.1016/j.cclet.2010.03.012

  日期：2010.7

  Sulfamic acid has been proved to be the most efficient and recyclable catalyst in carbamate synthesis from alkylamine and dialkyl carbonate. High selectivity, cost-efficiency and simple product separation were the advantageous features obtained in this process. Sulfamic acid could be reused several times and keep its initial activity in the recycle runs. In addition, sulfamic acid has also exhibited the potential catalytic ability for alkylation of aromatic amines. (C) 2010 Bo Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.