2,6-lutidine-bromine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-lutidine-bromine
• 英文别名: 2,6-Dimethylpyridine;molecular bromine
• 化学式: Br₂*C₇H₉N
• 分子量: 266.963
• InChiKey: DBFCPKQFYYTEKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.39
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-lutidine-bromine 以 乙醚 、 二氯甲烷 为溶剂， 以43%的产率得到
  参考文献：
  名称：

  The bromination of purines with a charge transfer complex between bromine and lutidine

  摘要：

  Diaminopurines, immobilized on a polymeric support are treated with a charge transfer complex of bromine and lutidine to afford 8-brominated derivatives. An ionic complex of bromine and lutidine did not oxidize the purines. 2,6-Dialkyl-aminopurines could also be oxidized on the alpha -carbon of their 2-alkylamino group. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01246-1
• 作为产物：
  描述：

  2,6-二甲基吡啶 在 溴 作用下， 以69.28%的产率得到2,6-lutidine-bromine
  参考文献：
  名称：

  The bromination of purines with a charge transfer complex between bromine and lutidine

  摘要：

  Diaminopurines, immobilized on a polymeric support are treated with a charge transfer complex of bromine and lutidine to afford 8-brominated derivatives. An ionic complex of bromine and lutidine did not oxidize the purines. 2,6-Dialkyl-aminopurines could also be oxidized on the alpha -carbon of their 2-alkylamino group. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01246-1
• 作为试剂：
  描述：

  p-nitrobenzyl 7-phthalimido-3-methylenecepham-4-carboxylate sulfoxide 在 三溴化磷 、 2,6-lutidine-bromine 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 25.0h， 生成 p-nitrobenzyl 7-phthalimido-3-bromomethyl-3-cephem-4-carboxylate
  参考文献：
  名称：

  Balsamo; Epifani; Giorgi, Farmaco, Edizione Scientifica, 1981, vol. 36, # 8, p. 705 - 710

  摘要：

  DOI：

文献信息

• The bromination of purines with a charge transfer complex between bromine and lutidine
  作者：Wolfgang K.-D Brill、Claudia Riva-Toniolo

  DOI：10.1016/s0040-4039(01)01246-1

  日期：2001.9

  Diaminopurines, immobilized on a polymeric support are treated with a charge transfer complex of bromine and lutidine to afford 8-brominated derivatives. An ionic complex of bromine and lutidine did not oxidize the purines. 2,6-Dialkyl-aminopurines could also be oxidized on the alpha -carbon of their 2-alkylamino group. (C) 2001 Elsevier Science Ltd. All rights reserved.