N-(4-vinylphenyl)pyridin-2-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-vinylphenyl)pyridin-2-amine
• 英文别名: N-(4-ethenylphenyl)pyridin-2-amine
• 化学式: C₁₃H₁₂N₂
• 分子量: 196.252
• InChiKey: UUQUOGYWFMRKRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基吡啶 、 4-乙烯基苯硼酸 在 potassium phosphate monohydrate 、 copper(II) acetate monohydrate 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以84%的产率得到N-(4-vinylphenyl)pyridin-2-amine
  参考文献：
  名称：

  Convenient copper-mediated Chan–Lam coupling of 2-aminopyridine: facile synthesis of N-arylpyridin-2-amines

  摘要：

  A new and practical process for the synthesis of N-arylpyridin-2-amine derivatives has been developed. Under the assistance of copper, the desired products were produced from commercially available 2-aminopyridine and aryl boronic acids in moderate to good yields with good functional group tolerance. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.06.092

文献信息

• Convenient copper-mediated Chan–Lam coupling of 2-aminopyridine: facile synthesis of N-arylpyridin-2-amines
  作者：Jianbin Chen、Kishore Natte、Nikki Y.T. Man、Scott G. Stewart、Xiao-Feng Wu

  DOI：10.1016/j.tetlet.2015.06.092

  日期：2015.8

  A new and practical process for the synthesis of N-arylpyridin-2-amine derivatives has been developed. Under the assistance of copper, the desired products were produced from commercially available 2-aminopyridine and aryl boronic acids in moderate to good yields with good functional group tolerance. (C) 2015 Elsevier Ltd. All rights reserved.