十二烷基膦酸二丁酯 | 5929-68-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 十二烷基膦酸二丁酯
• 英文名称: dodecyl-phosphonic acid dibutyl ester
• 英文别名: Dodecan-phosphonsaeure-(1)-dibutylester；Dodecyl-phosphonsaeure-dibutylester；Dodecanphosphonsaeure-dibutylester；Dodecylphosphonsaeure-dibutylester；Dodecylphosphonsaeuredibutylester；1-Dibutoxyphosphoryldodecane
• CAS: 5929-68-0
• 化学式: C₂₀H₄₃O₃P
• 分子量: 362.533
• InChiKey: AYFPSZCGLIBPRO-UHFFFAOYSA-N

物化性质

• 沸点：
  145-175 °C(Press: 0.9 Torr)
• 密度：
  0.913 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  24
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

上下游信息

• 下游产品

  中文名称	英文名称	CAS号	化学式	分子量
  ——	dodecylphosphonate de dimethyle	16693-57-5	C14H31O3P	278.372

反应信息

• 作为反应物：
  描述：

  十二烷基膦酸二丁酯 在 吡啶 、 五氯化磷 、 氢溴酸 作用下， 生成 dodecylphosphonate de dimethyle
  参考文献：
  名称：

  The Thermal Reaction between Alkylating Agents and Phosphonate or Phosphate Esters

  摘要：

  DOI：

  10.1021/jo01050a077
• 作为产物：
  描述：

  二丁基亚磷酸钠 、 溴代十二烷 生成 十二烷基膦酸二丁酯
  参考文献：
  名称：

  The Thermal Reaction between Alkylating Agents and Phosphonate or Phosphate Esters

  摘要：

  DOI：

  10.1021/jo01050a077

文献信息

• Lubricating oil composition and use thereof
  申请人：JAPAN SUN OIL COMPANY, LTD.

  公开号：EP0510633A1

  公开（公告）日：1992-10-28

  The present invention provides a lubricating oil composition for refrigerating machine capable of enhancing the anti-wear property of the entire system when used together with 1,1,1,2-tetrafluoroethane (HFC-134a) which does not act as an extreme-pressure agent. This composition exhibits an anti-wear property superior to that of the existing lubricating oil composition for refrigerating machine using CFC-12. The ester expressed in any one of Formulae (I), (V), (VI) is used as the base oil or as an additive to the base oil. (The symbols in the formulae are as specified in Specification herein.)

  本发明提供了一种用于制冷机的润滑油组合物，该组合物与不作为极压剂的 1,1,1,2- 四氟乙烷（HFC-134a）一起使用时，能够提高整个系统的抗磨损性能。 这种组合物的抗磨损性能优于使用 CFC-12 的现有制冷机润滑油组合物。 式（I）、（V）、（VI）中任一式所表示的酯可用作基础油或基础油的添加剂（式中符号如本说明书所述）。
• Geiseler,G. et al., Chemische Berichte, 1960, vol. 93, p. 765 - 774
  作者：Geiseler,G. et al.

  DOI：——

  日期：——
• The Aqueous Solubility of Acetanilide
  作者：Thomas S. Logan

  DOI：10.1021/ja01223a046

  日期：1945.7
• US2397422
  申请人：——

  公开号：——

  公开（公告）日：——
• Eotaxin Expression by Epithelial Cells and Plasma Cells in Chronic Asthma
  作者：Rakesh K Kumar、Paul S Thomas、Da-Qiang Seetoo、Cristan Herbert、Andrew N J McKenzie、Paul S Foster、Andrew R Lloyd

  DOI：10.1038/labinvest.3780442

  日期：2002.4

  Chemoattractants such as eotaxin are believed to play an important role in the recruitment of eosinophils into the airways in asthma. We investigated expression of eotaxin in the airway wall in a model of chronic human asthma, in which systemically sensitized mice were exposed to low mass concentrations of aerosolized antigen for 6 weeks. In these animals, the number of intraepithelial eosinophils in the airways was significantly increased 3 hours after exposure and declined by 24 hours. In parallel, immunoreactivity for eotaxin was strikingly up-regulated in airway epithelial cells and in inflammatory cells in the lamina propria. The latter were identified as plasma cells by double immunofluorescent labeling. Increased expression of eotaxin by epithelial cells and plasma cells was also demonstrated in a case of fatal human asthma. In contrast, sensitized mice that received a single exposure to a high mass concentration of aerosolized antigen exhibited delayed eosinophil recruitment, which did not correlate with eotaxin expression. Furthermore, in sensitized chronically exposed interieukin-13-deficient mice there was virtually no recruitment of eosinophils into the airways, although eotaxin expression was greater than or equal to that in wild-type mice. These results indicate that there are striking differences between acute and chronic exposure models in the time course of eotaxin expression and eosinophil recruitment. Although high eotaxin levels alone are not sufficient to cause recruitment of eosinophils into the airways, recurrent exposure may generate or up-regulate additional signals required for eosinophil chemotaxis.