copper pivalate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: copper pivalate
• 英文别名: copper(I) pivalate；Copper(1+);2,2-dimethylpropanoate；copper(1+);2,2-dimethylpropanoate
• 化学式: C₅H₉O₂*Cu
• 分子量: 164.671
• InChiKey: QWLDGFJOWIBTBQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.22
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  [Cu16(μ4-O)4(μ4-OH)2(μ-OH)2(pivalate)12(1-propylate)8]*3(1-propanol) 以 neat (no solvent, solid phase) 为溶剂， 生成 copper pivalate
  参考文献：
  名称：

  1D Helical Polymeric Chain with a Pseudo-5₃ Screw Axis Formed by Cuprophilicity. Synthesis and Crystal Structure of Copper(I) Pivalate

  摘要：

  A coordination polymer, [Cu-5(piv)(5)](n) (piv = pivalate), was prepared by a thermal decomposition method. The unit cell of the crystal structure consisted of one right-handed helical chain and one left-handed helical chain, which were formed by an alternation of Cu-I ions and carboxylate (O-C-O) groups. This chain possessed a pseudo-5(3) screw axis; the second-order structure was suggested to be realized by a balance between the cuprophilicity and a steric effect of the tert-butyl groups.

  DOI：

  10.1021/ic060989b
• 作为试剂：
  描述：

  O-苄基羟胺 、 氯化二乙基铝 在 copper pivalate 作用下， 以 苯 为溶剂， 反应 1.0h， 以87%的产率得到N,N-二乙基-O-苄基羟胺
  参考文献：
  名称：

  使用铜（II）-铝（III）对进行芳香胺和相关化合物的烷基化

  摘要：

  描述了使用烷基铝试剂的铜（II）介导的胺和相关化合物（例如肼，，羟胺）的烷基化。利用金属-金属交换作为关键步骤，反应以高收率选择性地进行。

  DOI：

  10.1016/0040-4039(96)00579-5

文献信息

• Copper(I) formate complexes
  申请人：Wittenbecher Lars

  公开号：US20070197810A1

  公开（公告）日：2007-08-23

  Copper(I) formate complexes of the formula L n Cu(HCOO).x HCOOH, where x is from 0 to 10, n is 1, 2, 3 or 4 and the n ligands L, independently of one another, are each one of the following ligands: a phosphane of the formula R 1 R 2 R 3 P; a phosphite of the formula (R 1 O)(R 2 O)(R 3 O)P; an isocyanide of the formula R 1 —NC; an alkene of the formula R 1 R 2 C═CR 3 R 4 ; or an alkyne of the formula R 1 C≡CR 2 ; where R 1 , R 2 , R 3 and R 4 , independently of one another, are hydrogen, a linear or branched, optionally partly or completely fluorinated alkyl, aminoalkyl, alkoxyalkyl, hydroxyalkyl, phosphinoalkyl or aryl radical of one to 20 carbon atoms; with the exception of triphenylphosphinocopper(I) formate and 1,1,1-tris(diphenyl-phosphinomethyl)ethanecopper(I) formate; are decomposed for depositing metallic copper.

  铜（I）甲酸盐配合物的化学式为LnCu（HCOO）。x HCOOH，其中x取值范围为0至10，n为1、2、3或4，而n配体L独立地可以是以下任一种配体：磷化物的化学式为R1R2R3P；亚磷酸酯的化学式为（R1O）（R2O）（R3O）P；异氰化物的化学式为R1—NC；烯烃的化学式为R1R2C═CR3R4；或炔烃的化学式为R1C≡CR2；其中R1、R2、R3和R4独立地可以是氢、直链或支链的、部分或完全氟化的烷基、氨基烷基、烷氧基烷基、羟基烷基、膦烷基或芳基，碳原子数为1至20；除了三苯基膦铜（I）甲酸盐和1,1,1-三（二苯基膦甲基）乙烷铜（I）甲酸盐之外，这些配合物可分解以沉积金属铜。
• METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING PALLADIUM COMPOUND
  申请人：Komiyama Masato

  公开号：US20130158272A1

  公开（公告）日：2013-06-20

  The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C 1 -C 40 carboxylic acid, and at least one kind of additive.

  本发明提供了一种生产黄嘌呤氧化酶抑制剂的方法，该抑制剂是治疗高尿酸血症的药物，或者其中间体，该方法高效且使用流程简短。本发明是一种新型耦合方法，通过在钯化合物、能够配位到钯化合物的配体、碱、C1-C40羧酸和至少一种添加剂的存在下，在式（1）所代表的化合物和式（2）所代表的化合物之间引发耦合反应，从而获得式（3）所代表的化合物。
• METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING A PALLADIUM COMPOUND
  申请人：Teijin Pharma Limited

  公开号：EP2610248A1

  公开（公告）日：2013-07-03

  The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C1-C40 carboxylic acid, and at least one kind of additive.

  本发明提供了一种生产作为高尿酸血症治疗药物的黄嘌呤氧化酶抑制剂或其中间体的方法，所述方法高效且工艺流程短。本发明是一种新颖的偶联方法，通过在钯化合物、能与钯化合物配位的配体、碱、C1-C40 羧酸和至少一种添加剂存在下，使式（1）代表的化合物与式（2）代表的化合物发生偶联反应，得到式（3）代表的化合物。
• Il'ina, E. G.; Santalova, N. A.; Dunaeva, K. M., Russian Journal of Inorganic Chemistry, 1991, vol. 36, p. 1297 - 1299
  作者：Il'ina, E. G.、Santalova, N. A.、Dunaeva, K. M.

  DOI：——

  日期：——
• US7777059B2
  申请人：——

  公开号：US7777059B2

  公开（公告）日：2010-08-17