十溴联苯 | 13654-09-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 十溴联苯
• 中文别名: 2,2,3,3,4,4,5,56,6-十溴代-1,1-联苯；2,2",3,3",4,4",5,5"6,6"-十溴代-1,1"-联苯
• 英文名称: Decabromobiphenyl
• 英文别名: Decabrombiphenyl；1,2,3,4,5-pentabromo-6-(2,3,4,5,6-pentabromophenyl)benzene
• CAS: 13654-09-6
• 化学式: C₁₂Br₁₀
• 分子量: 943.172
• InChiKey: AQPHBYQUCKHJLT-UHFFFAOYSA-N

物化性质

• 熔点：
  378-379℃
• 沸点：
  568.3±45.0 °C(Predicted)
• 密度：
  2.979±0.06 g/cm3(Predicted)
• 溶解度：
  氯仿（微溶）、THF（微溶）
• 颜色/状态：
  White solid
• 蒸汽压力：
  3.98X10-10 mm Hg at 25 °C

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

代谢

从自然水域捕获的鱼类的分析也可能表明鱼类发生脱溴反应的可能性，除非发生选择性积累或消除。在主要被十溴联苯污染的水域中捕获的鱼类中，仅存在非溴代和六溴联苯同系物。

Analyses of fish captured from natural waters may also indicate the possibility of the debromination reaction in fish, unless selective accumulation or elimination takes place. In fish from water mainly contaminated with decabromobiphenyl, only the nona- and hexa bromobiphenyl congeners were present.

来源:Hazardous Substances Data Bank (HSDB)

代谢

多溴联苯（PBBs）可以通过口服、吸入和皮肤途径被吸收。由于它们的亲脂性，尤其是高溴代的多溴联苯，倾向于在富含脂质的组织中积累，如肝脏、脂肪、皮肤和母乳。某些多溴联苯化合物通过由苯巴比妥诱导的细胞色素P-450类型的微粒体单加氧酶系统进行代谢。代谢速率可能取决于溴取代模式。低溴含量的多溴联苯同系物转化为主要在尿液中排出的羟基衍生物。高溴代同系物要么被保留，要么在粪便中不变排出。(L628)

PBBs can be absorbed via oral, inhalation, and dermal routes. Due to their lipophilic nature, PBBs, especially the highly brominated congeners, tend to accumulate in lipid-rich tissues such as the liver, adipose, skin, and breast milk. Certain PBB compounds are metabolized by the microsomal monooxygenase system catalyzed by cytochrome P-450 of the type induced by phenobarbital. The rate of metabolism may depends on the bromine substitution pattern. PBB congeners of low bromine content are transformed into hydroxylated derivatives that are predominately eliminated in the urine. Highly brominated congeners are either retained or excreted unchanged in the feces. (L628)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

多氯联苯（PBBs）的毒性机制因具体同系物而异。主要的相互作用被认为是涉及芳基烃受体（AhR）。PBBs与AhR结合并激活它，进而启动一系列基因的转录上调，影响生化途径和内分泌途径、细胞周期调节、形态发生、氧化应激反应以及各种其他过程。这导致PBBs特有的多种毒性反应。一些已知的诱导基因包括细胞色素P-450依赖性单加氧酶CYP1A1和CYP1A2。

The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR). PBBs bind to and activate the AhR, which in turn initiates the transcriptional upregulation of a number of genes, affecting biochemical and endocrine pathways, cell cycle regulation, morphogenesis, oxidative stress response, and various other processes. This results in the numerous toxic responses characteristic of PBBs. Some of the known induced genes include the cytochrome P-450-dependent monooxygenases CYP1A1 and CYP1A2. (L628)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

2A，可能对人类致癌。（L135）

2A, probably carcinogenic to humans. (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

PBB暴露可能会导致体重减轻、皮肤问题（如痤疮）、神经和免疫系统的影响，以及对肝脏、肾脏和甲状腺的影响。

PBB exposure may cause weight loss, skin disorders (such as acne), nervous and immune systems effects, and effects on the liver, kidneys, and thyroid gland. (L628)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L628）；吸入（L628）；皮肤给药（L628）

Oral (L628) ; inhalation (L628) ; dermal (L628)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

PBB暴露的症状可能包括恶心、腹痛、食欲不振、关节痛、疲劳和虚弱。

Symptoms of PBB exposure may include nausea, abdominal pain, loss of appetite, joint pain, fatigue, and weakness. (L629)

来源:Toxin and Toxin Target Database (T3DB)

安全信息

• 危险等级：
  9
• 海关编码：
  2903999010
• 包装等级：
  II
• 危险类别：
  9

反应信息

• 作为产物：
  描述：

  联苯 在 aluminum tri-bromide 、 溴 作用下， 反应 4.0h， 生成 十溴联苯 、 2,2',3,3',4,4',5,5',6-壬溴联苯
  参考文献：
  名称：

  Anaerobic transformation of polybrominated biphenyls with the goal of identifying unknown hexabromobiphenyls in Baltic cod liver

  摘要：

  Polybrominated biphenyls (PBBs) have been introduced as flame retardants in 1970. Despite decreasing application rates since the mid-1970s, PBB residues are still reported in the environment. Furthermore, environmental PBB residues often do not match the PBB pattern in technical products. To get insights into the structures of environmentally-relevant PBBs, the congener patterns of technical hexabromobiphenyl (THBB), octabromobiphenyl (TOBB), synthesized PBB 209 were compared to PBB residues in a cod liver sample from the Baltic Sea. The most relevant PBB congeners in Baltic cod liver were not present in the technical products and therefore most likely metabolites. For this reason, TOBB and HPLC-fractions obtained from this technical product were incubated with super-reduced cyanocobalamine. Reductive debromination was found to be the predominant transformation process. Bromine substituents in ortho-positions proved to be more recalcitrant, and several of the unknown PBBs were tri- and tetra-ortho substituted congeners. Furthermore, the key-PBBs determined in Baltic cod liver were formed during this process. The most important hexabromobiphenyl in Baltic cod liver was identified as PBB 155 by parallel synthesis. PBB 155 which was not detected in the technical PBB product analyzed was suggested as an indicator PBB congener suited to decide whether PBB residues originate from the previous use of THBB (low relative abundance of PBB 155) or TOBB/TDBB (high relative abundance of PBB 155). The latter scenario was found to be valid for the Baltic cod liver sample. Thus, PBBs in the Baltic Sea appeared to originate from partially-weathered residues of PBB 209. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.chemosphere.2007.08.051

文献信息

• TRANSPARENT FILM
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20170313728A1

  公开（公告）日：2017-11-02

  The object of the present invention is to attain water repellency as well as the heat resistance and the light resistance. the transparent film of the present invention comprises: a polysiloxane backbone; and a trialkylsilyl containing molecular chain bonded to a part of silicon atoms forming the polysiloxane backbone, wherein alkyl groups in the trialkylsilyl containing molecular chain may be replaced by fluoroalkyl groups, and the transparent film satisfies at least one of the relationships of: ( B H −A 0 )/ A 0 ×100(%)≧−27(%); and ( B L −A 0 )/ A 0 ×100(%)≧−15(%), provided that A 0 is an initial contact angle of a liquid droplet on the transparent film, B H is a contact angle of a liquid droplet on the transparent film incubated at 200° C. for 24 hours, and B L is a contact angle of a liquid droplet on the transparent film irradiated by a xenon lamp with an intensity of 250 W for 100 hours.

  本发明的目的是实现水的防水性以及耐热性和耐光性。该透明薄膜包括：聚硅氧烷骨架；以及连接到形成聚硅氧烷骨架的部分硅原子上的三烷基硅基含有分子链，其中三烷基硅基含有分子链中的烷基可以被氟烷基所取代，且透明薄膜满足以下关系式中的至少一种：(BH−A0)/A0×100(%)≧−27(%)；和(BL−A0)/A0×100(%)≧−15(%)，其中A0是液滴在透明薄膜上的初始接触角，BH是在200℃下孵育24小时后液滴在透明薄膜上的接触角，而BL是在250W的氙灯照射下100小时后液滴在透明薄膜上的接触角。
• [EN] AMINOGUANIDINEPHENYLPHOSPHINATE FLAME RETARDANT COMPOSITIONS<br/>[FR] COMPOSITIONS IGNIFUGES À BASE D'AMINOGUANIDINEPHÉNYLPHOSPHINATE
  申请人：BASF SE

  公开号：WO2011138410A1

  公开（公告）日：2011-11-10

  The present invention relates to flame retardant polymer compositions which comprise aminoguanidine phenylphosphinates and mixtures with additional flame retardants. The compositions are especially useful for the manufacture of flame retardant compounds based on polyfunctional epoxides or polycondensates like polyesters, polyamides and polycarbonates.

  本发明涉及含有氨基胍苯基膦酸盐和其他阻燃剂混合物的阻燃聚合物组合物。该组合物特别适用于制造基于多官能团环氧树脂或聚酯、聚酰胺和聚碳酸酯的阻燃化合物。
• [EN] CONDENSATION PRODUCTS OF MELAMINE AND PHENYLPHOSPHONIC ACID AND THEIR USE AS FLAME RETARDANTS<br/>[FR] PRODUITS DE CONDENSATION DE MÉLAMINE ET DE L'ACIDE PHÉNYLPHOSPHONIQUE ET LEUR UTILISATION COMME IGNIFUGES
  申请人：BASF SE

  公开号：WO2012123870A1

  公开（公告）日：2012-09-20

  Condensation products of melamine and phenylphophonic acid, a process for their preparation, their compositions with polymeric materials and their use as flame retardants in polymer substrates are provided. The compositions are especially useful for the manufacture of flame retardant compounds based on polyfunctional epoxides or polycondensates, such as polyesters, polyamides and polycarbonates.

  本发明提供了三聚氰胺和苯基膦酸的缩合产物，它们的制备方法，以及它们与聚合材料的组合物和它们作为聚合物基底中阻燃剂的使用。这些组合物特别适用于基于多官能羟基化合物或多缩聚物，如聚酯、聚酰胺和聚碳酸酯的阻燃化合物的制造。
• Insulating material containing cycloolefin polymer
  申请人：——

  公开号：US20040157039A1

  公开（公告）日：2004-08-12

  An insulating material comprising a cycloolefin polymer, specifically, an interlayer insulating material for a high-density assembly board having interlayer-connecting via holes at most 200 &mgr;m in diameter, comprising a cycloolefin polymer containing at least 50 mol % of a repeating unit derived from a cycloolefin monomer; a dry film formed from a curable resin composition comprising a polymer having a number average molecular weight within a range of 1,000 to 1,000,000 as measured by gel permeation chromatography, and a hardener; and a resin-attached metal foil obtained by forming a film of a cycloolefin polymer on one side of a metal foil. Laminates, multi-layer laminates and build-up multi-layer laminates making use of these materials, and production processes thereof.

  一种绝缘材料，包括环氧烷基聚合物，具体地说，这是一种用于高密度组装板的层间绝缘材料，其间层连接的经孔直径最多为200微米，包括至少50摩尔％来自环氧烷基单体的重复单元的环氧烷基聚合物; 由可固化树脂组成的可干膜，其聚合物的数量平均分子量在1,000至1,000,000之间（通过凝胶渗透色谱法测量），以及硬化剂; 以及通过在金属箔的一侧形成环氧烷基聚合物膜而获得的树脂附着金属箔。利用这些材料制成的层压板，多层层压板和堆叠多层层压板以及其生产工艺。
• Thermoplastic resin composition and production method thereof
  申请人：Takei Seiji

  公开号：US20050014003A1

  公开（公告）日：2005-01-20

  The present invention provides a thermoplastic resin composition comprising a thermoplastic resin (A), an acrylic polymer (B), a polytetrafluoroethylene-containing powder mixture (C) and a filler (D), the amount of the acrylic polymer (B) being from 0.1 to 400 parts by weight, the amount of the filler (D) being from 1 to 2000 parts by weight, based on 100 parts by weight of the thermoplastic resin (A), and the amount of a polytetrafluoroethylene component in the polytetrafluoroethylene-containing powder mixture (C) is from 0.01 to 400 parts by weight based on 100 parts by weight of the thermoplastic resin (A).

  本发明提供一种热塑性树脂组合物，包括热塑性树脂(A)、丙烯酸聚合物(B)、聚四氟乙烯含量的粉末混合物(C)和填料(D)，其中丙烯酸聚合物(B)的用量为热塑性树脂(A)的100份重量中的0.1至400份重量，填料(D)的用量为热塑性树脂(A)的100份重量中的1至2000份重量，聚四氟乙烯组分在聚四氟乙烯含量的粉末混合物(C)中的用量为热塑性树脂(A)的100份重量中的0.01至400份重量。

表征谱图