tert-butyl (R,R)-2,2-dimethyl-4-[3-trimethylsilanyl-propa-1,2-dienyl]-oxazolidine-3-carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: tert-butyl (R,R)-2,2-dimethyl-4-[3-trimethylsilanyl-propa-1,2-dienyl]-oxazolidine-3-carbamate
• 英文别名: tert-butyl (R,R)-2,2-dimethyl-4-[3-trimethylsilanyl-propa-1,2-dienyl]-oxazolidine-3-formate
• 化学式: C₁₆H₂₉NO₃Si
• 分子量: 311.497
• InChiKey: KMWNDEXDRMLINC-WCRCJTMVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.95
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  六甲基二硅烷 、 tert-butyl (4S)-2,2-dimethyl-4-((1R)-1-acetoxy-prop-2-inyl)-oxazolidine-3-carbamate 在 甲基锂 、 copper(l) cyanide 作用下， 以 四氢呋喃 为溶剂， 以67%的产率得到tert-butyl (R,R)-2,2-dimethyl-4-[3-trimethylsilanyl-propa-1,2-dienyl]-oxazolidine-3-carbamate
  参考文献：
  名称：

  New enantiomerically enriched amino allyl- and allenylsilanes derived from naturally occurring amino acids

  摘要：

  Some enantiomerically enriched Z-amino allylsilanes and allenylsilanes have been obtained selectively through the synthetic elaboration of naturally occurring amino acids. Fluorodesilylation with Selectfluor (R) has been proved as an easy way for preparing allylic fluorides bearing an amino or an amino acid moiety on the lateral chain. In particular, a new unsaturated fluorinated amino acid has been obtained, albeit as a diastereomeric mixture. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.12.025

文献信息

• New enantiomerically enriched amino allyl- and allenylsilanes derived from naturally occurring amino acids
  作者：Gianna Reginato、Alessandro Mordini、Alice Tenti、Michela Valacchi、Julie Broguiere

  DOI：10.1016/j.tetasy.2008.12.025

  日期：2008.12

  Some enantiomerically enriched Z-amino allylsilanes and allenylsilanes have been obtained selectively through the synthetic elaboration of naturally occurring amino acids. Fluorodesilylation with Selectfluor (R) has been proved as an easy way for preparing allylic fluorides bearing an amino or an amino acid moiety on the lateral chain. In particular, a new unsaturated fluorinated amino acid has been obtained, albeit as a diastereomeric mixture. (C) 2009 Elsevier Ltd. All rights reserved.