4-(4-benzoylphenoxy)butyric acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-benzoylphenoxy)butyric acid
• 英文别名: 4-(4′-benzoylphenoxy)butanoic acid；4-(4-Benzoylphenoxy)butanoic acid
• 化学式: C₁₇H₁₆O₄
• 分子量: 284.312
• InChiKey: SVHCXCPSJLSTKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(4-benzoylphenoxy)butyric acid 在 N-碘代丁二酰亚胺 、 碘 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 8.0h， 以84%的产率得到4-(3-iodopropoxy)benzophenone
  参考文献：
  名称：

  用 NIS 和 NCS/NaI 将脂肪族羧酸一锅法转化为 N-烷基琥珀酰亚胺

  摘要：

  在加热条件下，用 N-碘代琥珀酰亚胺 (NIS) 在 1,2-二氯乙烷中处理初级脂肪族羧酸以形成相应的烷基碘。基于这些结果，这些脂肪族羧酸用 NIS 处理，然后与 K2CO3 反应，在一锅中以良好的收率得到相应的 N-烷基琥珀酰亚胺。此外，这些脂肪族羧酸用 N-氯代琥珀酰亚胺 (NCS) 和 NaI 处理，然后与 K2CO3 反应以在一锅中以良好到中等的收率提供相应的 N-烷基琥珀酰亚胺。通过使用本方法，用 NIS、K2CO3 和肼连续处理伯脂肪族羧酸 (10 mmol)，然后以良好的收率提供相应的脱羧伯胺。

  DOI：

  10.1002/ejoc.201501315
• 作为产物：
  描述：

  4-羟基-二苯甲酮 在 水 、 potassium carbonate 、 potassium hydroxide 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 14.25h， 生成 4-(4-benzoylphenoxy)butyric acid
  参考文献：
  名称：

  Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity

  摘要：

  2-硝基苯甲醇被开发为一种具有胺选择性的新型光反应基团，表现出对生物分子的高效标记和交联作用。

  DOI：

  10.1039/c9cc09449k

文献信息

• Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system
  作者：R.John Scott、Lu-Yun Lian、S.Hanna Muharram、Alan Cockayne、Stewart J Wood、Barrie W Bycroft、Paul Williams、Weng C Chan

  DOI：10.1016/s0960-894x(03)00497-9

  日期：2003.8

  The expression of many staphylococcal virulence factors are regulated by the agr locus via a two-component signal transduction system (TCSTS), which is activated in response to a secreted autoinducer peptide (AIP). By exploiting the unique chemical architecture of the naturally occurring AIP-1, several potent inhibitors of staphylococcal TCSTS were designed and synthesized using either a linear or branched solid-phase approach. These inhibitors are competitive binders and contain the crucial 16-membered side-chain-to-tail thiolactone peptide pharmacophore. (C) 2003 Elsevier Ltd. All rights reserved.
• Photoinduced Signal Amplification Through Externally Sensitized Photofragmentation in Masked Photosensitizers
  申请人：Kutateladze Andrei G.

  公开号：US20080312092A1

  公开（公告）日：2008-12-18

  A method of photochemically amplifying the chemical signal associated with unmasking a photosensitizer and releasing a radical leaving group when a photochemical chain reaction is initiated by a sensitizer attached to a molecule of interest is provided. More specifically, provided is a method of photoinduced amplification comprising: providing a plurality of masked photosensitizers, each masked photosensitizer having a masking group bonded to a photosensitizer through a releasable covalent bond which disrupts the conjugation of the photosensitizer; providing a reaction photosensitizer in releasing proximity to a first masked photosensitizer; exciting the reaction photosensitizer with photoradiation, whereby the reaction photosensitizer induces release of the masking group from the first masked photosensitizer, producing a first unmasked photosensitizer which induces release of the masking group from a second masked photosensitizer in releasing proximity to the first masked photosensitizer, and so on. The release of the masking group from masked photosensitizer continues as long as masked photosensitizers are in releasing proximity to the reaction photosensitizer, or until a side reaction occurs which stops the chain propagation, or until the source of light is turned off.
• PHOTOINDUCED SIGNAL AMPLIFICATION THROUGH EXTERNALLY SENSITIZED PHOTOFRAGMENTATION IN MASKED PHOTOSENSITIZERS AND PHOTOAMPLIFIED FLUORESCENCE TURN-OFF SYSTEM
  申请人：Kutateladze Andrei G.

  公开号：US20110117667A1

  公开（公告）日：2011-05-19

  Provided is a photoamplified fluorescence turn-off assay where a masked photosensitizer is mixed with a fluorescent molecule. This mixture is brightly fluorescent because the masked photosensitizer is not capable of quenching the fluorophore. When the photosensitizer is released and amplified, the photosensitizer quenches the emission of fluorophores very efficiently.
• US8735167B2
  申请人：——

  公开号：US8735167B2

  公开（公告）日：2014-05-27
• [EN] PHOTOINDUCED SIGNAL AMPLIFICATION THROUGH EXTERNALLY SENSITIZED PHOTOFRAGMENTATION IN MASKED PHOTOSENSITIZERS AND PHOTOAMPLIFIED FLUORESCENCE TURN-OFF SYSTEM<br/>[FR] AMPLIFICATION DE SIGNAL PHOTOINDUITE PAR PHOTOFRAGMENTATION SENSIBILISÉE DE MANIÈRE EXTERNE DANS DES PHOTOSENSIBILISATEURS MASQUÉS ET SYSTÈME D'INTERRUPTION DE FLUORESCENCE PHOTOAMPLIFIÉE
  申请人：COLORADO SEMINARY WHICH OWNS A

  公开号：WO2009026313A1

  公开（公告）日：2009-02-26

  PProvided is a photoamplified fluorescence turn-off assay where a masked photosensitizer is mixed with a fluorescent molecule. This mixture is brightly fluorescent because the masked photosensitizer is not capable of quenching the fluorophore. When the photosensitizer is released and amplified, the photosensitizer quenches the emission of fluorophores very efficiently.