cis-3-cyclopropylaminoacrylic acid methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis-3-cyclopropylaminoacrylic acid methyl ester
• 英文别名: methyl (Z)-3-(cyclopropylamino)prop-2-enoate
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: ZNWOGGJMSYSKHX-PLNGDYQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cis-3-cyclopropylaminoacrylic acid methyl ester 、 2,4-二氯苯甲酰氯 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以44%的产率得到3-cyclopropylamino-2-(2,4-dichlorobenzoyl)acrylic acid methyl ester
  参考文献：
  名称：

  Identification, biological activity, and mechanism of the anti-ischemic quinolone analog

  摘要：

  The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01 mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01 mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed that the anti-ischemic activity might exert via an anti-apoptotic pathway, which implies its therapeutic uses against the ischemic cell injuries including ischemic stroke and ischemic heart disease. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.07.009
• 作为产物：
  描述：

  丙炔酸甲酯 、 环丙胺 以 乙腈 为溶剂， 反应 3.0h， 以22%的产率得到cis-3-cyclopropylaminoacrylic acid methyl ester
  参考文献：
  名称：

  Identification, biological activity, and mechanism of the anti-ischemic quinolone analog

  摘要：

  The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01 mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01 mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed that the anti-ischemic activity might exert via an anti-apoptotic pathway, which implies its therapeutic uses against the ischemic cell injuries including ischemic stroke and ischemic heart disease. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.07.009

文献信息

• Identification, biological activity, and mechanism of the anti-ischemic quinolone analog
  作者：Chan-Hee Park、Jongwon Lee、Hwi Young Jung、Min Ji Kim、Sun Ha Lim、Hyung Tae Yeo、Eung Chil Choi、Eun Jeong Yoon、Kyu Won Kim、Jong Ho Cha、Seok-Ho Kim、Dong-Jo Chang、Do-Yeon Kwon、Funan Li、Young-Ger Suh

  DOI：10.1016/j.bmc.2007.07.009

  日期：2007.10

  The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01 mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01 mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed that the anti-ischemic activity might exert via an anti-apoptotic pathway, which implies its therapeutic uses against the ischemic cell injuries including ischemic stroke and ischemic heart disease. (c) 2007 Elsevier Ltd. All rights reserved.