1-bromo-2-(2,4-dichlorophenyl)prop-1-ene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-bromo-2-(2,4-dichlorophenyl)prop-1-ene
• 英文别名: 1-(1-bromoprop-1-en-2-yl)-2,4-dichlorobenzene；1-(1-Bromoprop-1-en-2-yl)-2,4-dichlorobenzene
• 化学式: C₉H₇BrCl₂
• 分子量: 265.965
• InChiKey: GCSKPDDDXOXPTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  7-methyl-3,4,5,10-tetrahydro-1H-2,5-methanoazepino[3,4-b]indole 、 1-bromo-2-(2,4-dichlorophenyl)prop-1-ene 在 copper(l) iodide potassium phosphate 、 L-脯氨酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 生成 9-[2-(2,4-Dichlorophenyl)prop-1-enyl]-5-methyl-9,12-diazatetracyclo[10.2.1.02,10.03,8]pentadeca-2(10),3(8),4,6-tetraene
  参考文献：
  名称：

  [EN] PYRIDO[3,4-B]INDOLES AND METHODS OF USE
  [FR] PYRIDO[3,4-B]INDOLES ET LEURS MÉTHODES D'UTILISATION

  摘要：

  这份披露涉及可用于调节个体组织中组胺受体的新杂环化合物。描述了吡啶并[3,4-b]吲哚，以及包含这些化合物的药物组合物和使用这些化合物进行各种治疗应用的方法，包括治疗认知障碍、精神障碍、神经递质介导的障碍和/或神经障碍。

  公开号：

  WO2011038163A1
• 作为产物：
  描述：

  2,4-二氯苯乙酮 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 乙醚 、 1,1,2,2-四氯乙烷 为溶剂， 反应 16.0h， 生成 1-bromo-2-(2,4-dichlorophenyl)prop-1-ene
  参考文献：
  名称：

  Synthesis, Fungicidal Activity, and QSAR of a Series of 2-Dichlorophenyl-3-triazolylpropyl Ethers

  摘要：

  A series of new alkyl and arylalkyl ethers of 2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propanol, related to the fungicide tetraconazole, were synthesized and tested in vitro or in vivo against seven common pathogens in comparison with tetraconazole. In vitro, most of them exhibited a broad spectrum of activity and an efficacy of the same order of magnitude of the standard, but the activity was influenced by the nature of the substituents. A QSAR study showed that lipophilicity is a major positive parameter in affecting the activity; the second relevant parameter is mu, whereas geometrical descriptors indicate that linear and narrow substituents are more suitable than wide ones. In in vivo assays some compounds had good activity on bean rust, either protective or curative. Sterol analysis showed that the mechanism of action is due to inhibition of 14 alpha-demethylase.

  DOI：

  10.1021/jf9906432

文献信息

• [EN] BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES PONTÉS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2009120720A1

  公开（公告）日：2009-10-01

  This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

  这项披露涉及可能用于调节个体组织中组胺受体的新化合物。描述了新的化合物，包括新的桥接杂环[4,3-b]吲哚化合物。还提供了药物组合物。提供了包含这些化合物的药物组合物，以及使用这些化合物在各种治疗应用中的方法，包括治疗认知障碍、精神障碍、神经递质介导的障碍和/或神经元障碍。
• AZEPINO[4,5-B]INDOLES AND METHODS OF USE
  申请人：Hung David T.

  公开号：US20100152163A1

  公开（公告）日：2010-06-17

  This disclosure relates to new azepino[4,5-b]indole compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new 1,2,3,4,5,6-tetrahydroazepino[4,5-b]indoles. Pharmaceutical compositions are also provided.

  本公开涉及新的azepino [4,5-b] indole化合物，可用于调节个体中的组胺受体。描述了新的化合物，包括新的1,2,3,4,5,6-六氢azepino [4,5-b] indoles。还提供了药物组合物。
• Azepino[4,5-B]indoles and methods of use
  申请人：Hung David T.

  公开号：US08569287B2

  公开（公告）日：2013-10-29

  This disclosure relates to new azepino[4,5-b]indole compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new 1,2,3,4,5,6-tetrahydroazepino[4,5-b]indoles. Pharmaceutical compositions are also provided.

  本公开涉及可用于调节个体组织胺受体的新的azepino [4,5-b] indole化合物。描述了新的化合物，包括新的1,2,3,4,5,6-六氢azepino [4,5-b] indoles。还提供了制药组合物。
• [EN] PYRIDO [3, 4-B] INDOLES AND METHODS OF USE<br/>[FR] PYRIDO[3,4-B]INDOLES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2009120717A3

  公开（公告）日：2009-12-03
• [EN] PYRIDO[3,4-B]INDOLES AND METHODS OF USE<br/>[FR] PYRIDO[3,4-B]INDOLES ET LEURS MÉTHODES D'UTILISATION
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2011038163A1

  公开（公告）日：2011-03-31

  This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

  这份披露涉及可用于调节个体组织中组胺受体的新杂环化合物。描述了吡啶并[3,4-b]吲哚，以及包含这些化合物的药物组合物和使用这些化合物进行各种治疗应用的方法，包括治疗认知障碍、精神障碍、神经递质介导的障碍和/或神经障碍。