(E)-N'-(2,5-dihydroxybenzylidene)-4-hydroxybenzohydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N'-(2,5-dihydroxybenzylidene)-4-hydroxybenzohydrazide
• 英文别名: N-[(E)-(2,5-dihydroxyphenyl)methylideneamino]-4-hydroxybenzamide
• 化学式: C₁₄H₁₂N₂O₄
• 分子量: 272.26
• InChiKey: XVFOKUVCSHJVIN-OVCLIPMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  102
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,5-二羟基苯甲醛 、 4-羟基苯甲酰肼 以 乙醇 为溶剂， 生成 (E)-N'-(2,5-dihydroxybenzylidene)-4-hydroxybenzohydrazide
  参考文献：
  名称：

  신규 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 이상세포 성장 질환의 예방 또는 치료용 약학적 조성물

  摘要：

  本发明涉及一种新型KDM4A (特异性去甲基化酶4A)抑制化合物、其制备方法以及包含其作为有效成分的预防或治疗异常细胞增长疾病的药学组合物。根据本发明，新型KDM4A抑制化合物不仅可以优异地抑制KDM4A的活性，还可以优异地抑制癌细胞的增殖活性，因此，包含其作为有效成分的KDM4A相关疾病，例如异常细胞增长疾病，例如癌症的预防或治疗药学组合物可以被有效地使用。

  公开号：

  KR101958107B1

文献信息

• 신규 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 이상세포 성장 질환의 예방 또는 치료용 약학적 조성물
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY 경상국립대학교산학협력단(220040107194) BRN ▼613-82-11653

  公开号：KR101958107B1

  公开（公告）日：2019-03-14

  본 발명은 신규 KDM4A(Lysine-specific demethylase 4A) 저해 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 이상세포 성장 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 신규 KDM4A 저해 화합물은, KDM4A(Lysine-specific demethylase 4A)의 활성을 우수하게 저해할 수 있을 뿐 아니라, 암 세포의 증식 활성을 우수하게 저해할 수 있는 바, 이를 유효성분으로 함유하는 KDM4A 관련 질환, 예를 들어 이상세포 성장 질환, 일례로 암 질환의 예방 또는 치료용 약학적 조성물로서 유용하게 사용될 수 있다.

  本发明涉及一种新型KDM4A (特异性去甲基化酶4A)抑制化合物、其制备方法以及包含其作为有效成分的预防或治疗异常细胞增长疾病的药学组合物。根据本发明，新型KDM4A抑制化合物不仅可以优异地抑制KDM4A的活性，还可以优异地抑制癌细胞的增殖活性，因此，包含其作为有效成分的KDM4A相关疾病，例如异常细胞增长疾病，例如癌症的预防或治疗药学组合物可以被有效地使用。
• Novel hydrazones
  申请人：——

  公开号：US20040110963A1

  公开（公告）日：2004-06-10

  The invention relates to novel hydrazone derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.

  本发明涉及新型腙类衍生物及其在制备药物组合物的活性成分中的应用。本发明还涉及相关方面，包括制备该化合物的过程、含有该化合物中的一种或多种的药物组合物，尤其是它们作为抗感染剂的应用。
• Design, synthesis and in vitro antimalarial activity of an acylhydrazone library
  作者：Patricia Melnyk、Virginie Leroux、Christian Sergheraert、Philippe Grellier

  DOI：10.1016/j.bmcl.2005.09.058

  日期：2006.1

  A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators. (c) 2005 Elsevier Ltd. All rights reserved.
• NOVEL HYDRAZONES
  申请人：Arpida AG,

  公开号：EP1404644A2

  公开（公告）日：2004-04-07
• [EN] NOVEL HYDRAZONES<br/>[FR] NOUVELLES HYDRAZONES
  申请人：ARPIDA AG

  公开号：WO2002070464A2

  公开（公告）日：2002-09-12

  The invention relates to novel hydrazone derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.