1-Phenyl-3-<3-(triethoxysilyl)propyl>triazene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Phenyl-3-<3-(triethoxysilyl)propyl>triazene
• 英文别名: 1-Phenyl-3-[3-(triethoxysilyl)propyl]triazene；N-(3-triethoxysilylpropyldiazenyl)aniline
• 化学式: C₁₅H₂₇N₃O₃Si
• 分子量: 325.483
• InChiKey: WMNMDETUDSZGPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Azirino[2',3'_3,4]pyrrolo[1,2-.α.]indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-6-hydroxy-8-(hydroxymethyl)-8a-methoxy-5-methyl-, 8-carbamate 、 1-Phenyl-3-<3-(triethoxysilyl)propyl>triazene 以 neat (no solvent) 为溶剂， 反应 2.0h， 以14%的产率得到[(4S,6S,7R,8S)-7-methoxy-12-methyl-10,13-dioxo-11-(3-triethoxysilylpropoxy)-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
  参考文献：
  名称：

  Preparation and antitumor activity of additional mitomycin A analogs

  摘要：

  On the basis of qualitative structure-activity relationships developed in the preceding article, a series of 32 new mitomycin A analogues were prepared and tested in antitumor screens. Seven of them gave greater prolongation of life (ILS) than mitomycin C in the mouse P388 leukemia assay. They included examples with 7-O substituents such as cyclic ethers and nitrogen heterocycles. A Hansch analysis was attempted with log P and MR as the independent variables, but no statistically significant correlation could be made. Seven compounds, chosen mainly for their good potency (MED), were tested in the subcutaneous B16 melanoma assay in mice and four of them showed greater ILS than mitomycin C.

  DOI：

  10.1021/jm00123a036
• 作为产物：
  描述：

  3-氨基丙基三乙氧基硅烷 、 benzenediazonium hexafluorophosphate 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以20%的产率得到1-Phenyl-3-<3-(triethoxysilyl)propyl>triazene
  参考文献：
  名称：

  Preparation and antitumor activity of additional mitomycin A analogs

  摘要：

  On the basis of qualitative structure-activity relationships developed in the preceding article, a series of 32 new mitomycin A analogues were prepared and tested in antitumor screens. Seven of them gave greater prolongation of life (ILS) than mitomycin C in the mouse P388 leukemia assay. They included examples with 7-O substituents such as cyclic ethers and nitrogen heterocycles. A Hansch analysis was attempted with log P and MR as the independent variables, but no statistically significant correlation could be made. Seven compounds, chosen mainly for their good potency (MED), were tested in the subcutaneous B16 melanoma assay in mice and four of them showed greater ILS than mitomycin C.

  DOI：

  10.1021/jm00123a036

文献信息

• SAMI, SALAH M.;REMERS, WILLIAM A.;BRADNER, WILLIAM T., J. MED. CHEM., 32,(1989) N, C. 703-708
  作者：SAMI, SALAH M.、REMERS, WILLIAM A.、BRADNER, WILLIAM T.

  DOI：——

  日期：——
• Preparation and antitumor activity of additional mitomycin A analogs
  作者：Salah M. Sami、William A. Remers、William T. Bradner

  DOI：10.1021/jm00123a036

  日期：1989.3

  On the basis of qualitative structure-activity relationships developed in the preceding article, a series of 32 new mitomycin A analogues were prepared and tested in antitumor screens. Seven of them gave greater prolongation of life (ILS) than mitomycin C in the mouse P388 leukemia assay. They included examples with 7-O substituents such as cyclic ethers and nitrogen heterocycles. A Hansch analysis was attempted with log P and MR as the independent variables, but no statistically significant correlation could be made. Seven compounds, chosen mainly for their good potency (MED), were tested in the subcutaneous B16 melanoma assay in mice and four of them showed greater ILS than mitomycin C.